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血小板功能的实验室研究:方法学综述

Laboratory investigation of platelet function: a review of methodology.

作者信息

Yardumian D A, Mackie I J, Machin S J

出版信息

J Clin Pathol. 1986 Jul;39(7):701-12. doi: 10.1136/jcp.39.7.701.

Abstract

Over the past decade interest in and knowledge about the role of platelets in the haemostatic process and in various pathological conditions has continued to grow. The scope of laboratory methodology to investigate platelet function in clinical haemorrhagic and thrombotic disorders in the specialised haemostasis unit has also proportionally widened. After highlighting the physiological processes of the role of platelets in the haemostatic mechanism this brief review comments critically on the available routine techniques used to study platelet function in patients who present primarily with a bleeding tendency.

摘要

在过去十年中,人们对血小板在止血过程及各种病理状况中的作用的兴趣和了解持续增长。在专门的止血科室中,用于研究临床出血性和血栓性疾病中血小板功能的实验室方法的范围也相应扩大。在强调了血小板在止血机制中的生理过程后,这篇简短的综述对主要表现为出血倾向的患者中用于研究血小板功能的现有常规技术进行了批判性评论。

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Familial haemostatic defect associated with reduced prothrombin consumption.
Br J Haematol. 1980 Feb;44(2):323-34. doi: 10.1111/j.1365-2141.1980.tb01215.x.
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Haemostasis. 1982;11(1):12-39. doi: 10.1159/000214638.
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A new congenital defect of platelet secretion: impaired responsiveness of the platelets to cytoplasmic free calcium.
Br J Haematol. 1983 Apr;53(4):543-57. doi: 10.1111/j.1365-2141.1983.tb07306.x.
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Depressed responsiveness to adrenaline in platelets from apparently normal human donors: a familial trait.
Br J Haematol. 1981 Oct;49(2):303-14. doi: 10.1111/j.1365-2141.1981.tb07227.x.
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Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents.
Br J Haematol. 1980 Nov;46(3):455-64. doi: 10.1111/j.1365-2141.1980.tb05993.x.

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