Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Resuscitation. 2018 Apr;125:79-82. doi: 10.1016/j.resuscitation.2018.02.006. Epub 2018 Feb 6.
Observational studies are prone to a number of biases. One of these is immortal time bias. In this manuscript, we discuss immortal time bias as it pertains to post-cardiac arrest research and describes a related bias which we term "resuscitation time bias". This bias can occur when studying exposures during cardiac arrest. In this unique situation, an exposure is more likely to occur the longer the cardiac arrest continues. Since length of resuscitation is strongly associated with worse outcome, this will bias the results toward a harmful effect of the exposure. We discuss this bias and present methods to account for it.
观察性研究容易受到多种偏倚的影响。其中之一是不朽时间偏倚。在本文中，我们讨论了与心脏骤停后研究相关的不朽时间偏倚，并描述了一种我们称之为“复苏时间偏倚”的相关偏倚。当研究心脏骤停期间的暴露时，可能会出现这种偏倚。在这种特殊情况下，暴露的可能性随着心脏骤停的持续时间的延长而增加。由于复苏时间与预后较差密切相关，这将使结果偏向于暴露的有害影响。我们讨论了这种偏倚，并提出了一些方法来解决它。
