Zhu Hui, Zhu Lijun, Fang Zhengmei, Yang Song, Chen Yanchun, Jin Yuelong, Zhao Xianghai, Shen Chong, Yao Yingshui
Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, Wuhu, China.
Department of Cardiology, Affiliated Yixing People's Hospital of Jiangsu University, People's Hospital of Yixing City, Yixing, China.
J Am Soc Hypertens. 2018 Mar;12(3):230-237.e12. doi: 10.1016/j.jash.2017.12.009. Epub 2017 Dec 28.
Somatostatin (SST) and growth hormone-releasing hormone (GHRH) are involved in the development of hypertension. This study aimed to evaluate whether SST and GHRH contribute to genetic susceptibility to hypertension. A case-control study consisting of 2012 hypertensive patients and 2210 matched control individuals was performed, and three tagging single-nucleotide polymorphisms were genotyped. The association of these single-nucleotide polymorphisms with hypertension and ischemic stroke was further evaluated among 4098 participants in a follow-up study. Hazard ratio (HR) and 95% confidence interval were estimated by Cox proportional hazards regression. The follow-up study indicated that in smoking population, variants at SST presented significant association with hypertension incidence; the adjusted HR of rs3755792 (GA + AA vs. GG) was 0.634 (P = .037), and the adjusted HR of rs7624906 (TC + CC vs. TT) was 1.803 (P = .005). In drinking population, rs3755792 at SST was associated with hypertension incidence, and the adjusted HR was 0.580 (P = .009). Moreover, rs6032470 at GHRH had a statistical association with ischemic stroke incidence in smoking population, and the adjusted HR of the additive model was 1.625 (P = .049). These results suggested that SST and GHRH harbor genetic susceptible loci with incident hypertension and ischemic stroke and that smoking and drinking might modify the genetic effect.
生长抑素（SST）和生长激素释放激素（GHRH）与高血压的发生有关。本研究旨在评估SST和GHRH是否会导致高血压的遗传易感性。开展了一项病例对照研究，纳入2012例高血压患者和2210例匹配的对照个体，并对三个标签单核苷酸多态性进行基因分型。在一项随访研究的4098名参与者中，进一步评估了这些单核苷酸多态性与高血压和缺血性中风的关联。通过Cox比例风险回归估计风险比（HR）和95%置信区间。随访研究表明，在吸烟人群中，SST基因变异与高血压发病率存在显著关联；rs3755792（GA + AA与GG相比）的调整后HR为0.634（P = 0.037），rs7624906（TC + CC与TT相比）的调整后HR为1.803（P = 0.005）。在饮酒人群中，SST的rs3755792与高血压发病率相关，调整后HR为0.580（P = 0.009）。此外，GHRH的rs6032470与吸烟人群的缺血性中风发病率存在统计学关联，加性模型的调整后HR为1.625（P = 0.049）。这些结果表明，SST和GHRH存在与高血压和缺血性中风发病相关的遗传易感位点，吸烟和饮酒可能会改变遗传效应。
