短潜伏期皮质内抑制降低与脑卒中患者捏力增强及运动功能良好恢复相关。
Decreased short-interval intracortical inhibition correlates with better pinch strength in patients with stroke and good motor recovery.
机构信息
Neurostimulation Laboratory, Neurology Clinical Division, Hospital das Clínicas/São Paulo University and Fundação Faculdade de Medicina, São Paulo, Brazil; NAPNA-USP (Núcleo de Apoio à Pequisa em Neurociência Aplicada), São Paulo University, São Paulo, Brazil.
Neurostimulation Laboratory, Neurology Clinical Division, Hospital das Clínicas/São Paulo University and Fundação Faculdade de Medicina, São Paulo, Brazil; NAPNA-USP (Núcleo de Apoio à Pequisa em Neurociência Aplicada), São Paulo University, São Paulo, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil.
出版信息
Brain Stimul. 2018 Jul-Aug;11(4):772-774. doi: 10.1016/j.brs.2018.01.030. Epub 2018 Feb 14.
BACKGROUND
Deeper short-interval intracortical inhibition (SICI), a marker of GABA activity, correlates with better motor performance in patients with moderate to severe hand impairments in the chronic phase after stroke.
OBJECTIVES
We evaluated the correlation between SICI in the affected hemisphere and pinch force of the paretic hand in well-recovered patients. We also investigated the correlation between SICI and pinch force in controls.
METHODS
Twenty-two subjects were included in the study. SICI was measured with a paired-pulse paradigm. The correlation between lateral pinch strength and SICI was assessed with Spearman's rho.
RESULTS
There was a significant correlation (rho = 0.69, p = 0.014) between SICI and pinch strength in patients, but not in controls. SICI was significantly deeper in patients with greater hand weakness.
CONCLUSIONS
These preliminary findings suggest that decreased GABA activity in M1 correlates with better hand motor performance in well-recovered subjects with stroke in the chronic phase.
背景
在脑卒中慢性期，运动表现较好的中度至重度手部运动障碍患者的大脑皮质内短间隔抑制（SICI）更深，这是 GABA 活性的标志物。
目的
我们评估了患侧半球 SICI 与麻痹手的捏力之间的相关性，同时还研究了对照组中 SICI 与捏力之间的相关性。
方法
本研究纳入了 22 名受试者。采用成对脉冲范式测量 SICI。使用 Spearman's rho 评估侧捏力与 SICI 之间的相关性。
结果
患者的 SICI 与捏力之间存在显著相关性（rho=0.69，p=0.014），但在对照组中没有相关性。手部无力越严重，SICI 越深。
结论
这些初步研究结果表明，在慢性期脑卒中后运动功能恢复良好的患者中，M1 中 GABA 活性的降低与手部运动功能的改善相关。
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