Department of Anatomic Pathology, Complejo Hospitalario Universitario de Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
Complejo Hospitalario Universitario de Ourense, C/ Ramón Puga Noguerol, 54, 32005, Ourense, Spain.
Mol Diagn Ther. 2018 Apr;22(2):169-177. doi: 10.1007/s40291-018-0315-2.
Neuroendocrine tumors (NETs) belong to a heterogeneous family of rare tumors with very broad and complex clinical behavior. Due to their heterogeneity, the lack of specific symptoms and the absence of sensitive methods for early detection, patients are usually diagnosed when the disease is in an advanced state for which curative treatments are scarce. In most cases, these few treatments try to prolong the survival of patients, maintaining the quality of life. The identification of biomarkers could help to improve early diagnosis and to choose the most suitable therapeutic strategy. This paper provides a review of the current histopathological diagnostic approaches for lung NET subtypes, including the predictive and prognostic factors, to help in the early diagnosis of this disease.
神经内分泌肿瘤（NETs）属于一组罕见肿瘤的异质性家族，具有非常广泛和复杂的临床行为。由于其异质性、缺乏特异性症状以及缺乏早期检测的敏感方法，患者通常在疾病处于晚期且治疗方法有限时才被诊断出来。在大多数情况下，这些为数不多的治疗方法旨在延长患者的生存时间，同时维持其生活质量。生物标志物的鉴定可能有助于改善早期诊断，并选择最合适的治疗策略。本文综述了肺 NET 亚型目前的组织病理学诊断方法，包括预测和预后因素，以帮助早期诊断这种疾病。
