Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.
Int J Biol Macromol. 2018 Jun;112:780-787. doi: 10.1016/j.ijbiomac.2018.02.030. Epub 2018 Feb 8.
The present paper reports graft copolymerization of N-vinylcaprolactam (NVCL) onto carboxymethylcellulose (CMC) using tert-butyl hydroperoxide (TBHP) initiator in N atmosphere. The grafting was found to be highest when concentrations of CMC, NVCL and TBHP were 6.25×10gdm, 10×10moldm and 20×10moldm respectively. The graft copolymer (CMC-g-PNVCL-1) was characterized by FTIR, HNMR, SEM, AFM, XRD and TGA analysis. The antioxidant activity of the graft copolymer was found to be higher (3.81%) than CMC and slightly less (5.47%) than the standard one (butylated hydroxytoluene, BHT). The hydroxyl radical scavenging activity of graft copolymer was found to be slightly less (13.69%) than CMC and more (44.20%) than the BHT. The hydrogen peroxide scavenging activity of graft copolymer was observed to be less (20.42%) than CMC and 53.34% less than BHT. The superoxide scavenging activity of graft copolymer was greater than the both. Compared to CMC the graft copolymer has shown greater antibacterial activity against S. aureus, Proteus vulgaris and S. typhi bacteria and less against Klebsiellapneumonia and Salmonella typhimurium.
本文报道了在氮气气氛中，以叔丁基过氧化氢（TBHP）为引发剂，将 N-乙烯基己内酰胺（NVCL）接枝到羧甲基纤维素（CMC）上的接枝共聚反应。当 CMC、NVCL 和 TBHP 的浓度分别为 6.25×10gdm、10×10moldm 和 20×10moldm 时，接枝率最高。接枝共聚物（CMC-g-PNVCL-1）通过 FTIR、HNMR、SEM、AFM、XRD 和 TGA 分析进行了表征。接枝共聚物的抗氧化活性（3.81%）高于 CMC，略低于标准品（丁基羟基甲苯，BHT）（5.47%）。接枝共聚物的羟基自由基清除活性略低于 CMC（13.69%），高于 BHT（44.20%）。接枝共聚物对过氧化氢的清除活性低于 CMC（20.42%），而 BHT 则低 53.34%。超氧阴离子清除活性大于两者。与 CMC 相比，接枝共聚物对金黄色葡萄球菌、普通变形杆菌和伤寒沙门氏菌的抗菌活性更强，对肺炎克雷伯菌和鼠伤寒沙门氏菌的抗菌活性更弱。
