Faculty of Medicine, Federal University of Uberlândia, MG, Brazil.
Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Diabetes Res Clin Pract. 2018 Oct;144:153-160. doi: 10.1016/j.diabres.2018.01.031. Epub 2018 Feb 8.
This study aimed to evaluate the correlations of glycemic variability with erythrocyte membrane stability parameters and oxidative stress markers in patients with type 1 diabetes mellitus (T1DM) under intensive treatment.
90 patients with T1DM and under intensive treatment of the disease were evaluated in relation to anthropometric indices, records of glycemic averages and parameters of glycemic variability, biochemical dosages (glucose, uric acid, lipidogram, glycated hemoglobin, microalbuminuria, creatinine and iron) reticulocyte count, erythrocyte membrane stability parameters and oxidative stress markers (thiobarbituric acid reactive substances, TBARS, and glutathione reductase, GR).
Indicators of glycemic variability in the short and long term showed correlations with parameters of membrane stability and markers of oxidative stress (GR). In addition, the comparison of these same parameters between the subgroups consisting of quartiles of GV or glycemic control also showed significant differences.
In the T1DM patients studied here, glycemic variability showed correlations with oxidative stress and erythrocyte membrane stability variables. This corroborates the hypothesis that glycemic fluctuations interfere with lipid peroxidation and cell membrane behavior, emphasizing its participation in mechanisms related to the development of chronic complications of diabetes.
本研究旨在评估强化治疗的 1 型糖尿病（T1DM）患者血糖变异性与红细胞膜稳定性参数和氧化应激标志物的相关性。
评估了 90 例 T1DM 患者的人体测量指数、血糖平均值和血糖变异性参数记录、生化检测（血糖、尿酸、血脂谱、糖化血红蛋白、微量白蛋白尿、肌酐和铁）、网织红细胞计数、红细胞膜稳定性参数和氧化应激标志物（硫代巴比妥酸反应物质，TBARS 和谷胱甘肽还原酶，GR）。
短期和长期血糖变异性指标与膜稳定性参数和氧化应激标志物（GR）相关。此外，还对由 GV 或血糖控制四分位数组成的亚组的这些相同参数进行了比较，结果显示差异具有统计学意义。
在本研究的 T1DM 患者中，血糖变异性与氧化应激和红细胞膜稳定性变量相关。这证实了血糖波动会干扰脂质过氧化和细胞膜行为的假设，强调了其在与糖尿病慢性并发症发展相关的机制中的参与。
