癌症分子标志物：癌症检测和管理指南。

Cancer molecular markers: A guide to cancer detection and management.

机构信息

Stem Cell Technology Laboratory, Centre for Scientific Research & Development, People's University, Bhopal, M.P., 462037, India; Biological Science Department, Rani Durgavati University, Jabalpur, M.P., 482001, India.

Biological Science Department, Rani Durgavati University, Jabalpur, M.P., 482001, India.

出版信息

Semin Cancer Biol. 2018 Oct;52(Pt 1):39-55. doi: 10.1016/j.semcancer.2018.02.002. Epub 2018 Feb 8.

DOI:10.1016/j.semcancer.2018.02.002

PMID:29428478

Abstract

Cancer is generally caused by the molecular alterations which lead to specific mutations. Advances in molecular biology have provided an impetus to the study of cancers with valuable prognostic and predictive significance. Over the hindsight various attempts have been undertaken by scientists worldwide, in the management of cancer; where, we have witnessed a number of molecular markers which allow the early detection of cancers and lead to a decrease in its mortality rate. Recent advances in oncology have led to the discovery of cancer markers that has allowed early detection and targeted therapy of tumors. In this context, current review provides a detail outlook on various molecular markers for diagnosis, prognosis and management of therapeutic response in cancer patients.

摘要

癌症通常是由导致特定突变的分子改变引起的。分子生物学的进展为具有重要预后和预测意义的癌症研究提供了动力。在回顾过去的过程中，世界各地的科学家在癌症的治疗方面进行了各种尝试；在这些尝试中，我们见证了许多分子标志物的出现，这些标志物可以帮助早期发现癌症并降低其死亡率。肿瘤学的最新进展导致了癌症标志物的发现，从而可以早期发现肿瘤并进行靶向治疗。在这种情况下，本综述详细介绍了用于癌症患者诊断、预后和治疗反应管理的各种分子标志物。