拉曼光谱评估口腔鳞状细胞癌下颌骨切除术切缘
Raman spectroscopy for assessment of bone resection margins in mandibulectomy for oral cavity squamous cell carcinoma.
机构信息
Department of Oral and Maxillofacial Surgery, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
Center for Optical Diagnostics and Therapy, Department of Dermatology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
出版信息
Eur J Cancer. 2018 Mar;92:77-87. doi: 10.1016/j.ejca.2018.01.068. Epub 2018 Feb 8.
OBJECTIVES
The aim of this study was to investigate the potential of Raman spectroscopy for detection of oral cavity squamous cell carcinoma (OCSCC) in bone resection surfaces during mandibulectomy.
MATERIALS & METHODS: Raman mapping experiments were performed on fresh mandible resection specimens from patients treated with mandibulectomy for OCSCC. A tumour detection algorithm was created based on water concentration and the high-wavenumber range (2800 cm-3050 cm) of the Raman spectra.
RESULTS
Twenty-six ex vivo Raman mapping experiments were performed on 26 fresh mandible resection specimens obtained from 22 patients. The algorithm was applied on an independent test set and showed an accuracy of 95%, a sensitivity of 95%, and a specificity of 87%.
CONCLUSION
These results form the basis for further development of a Raman spectroscopy tool as an objective method for intraoperative assessment of bone resection margins.
目的
本研究旨在探讨拉曼光谱在颌骨切除术骨切缘检测口腔鳞状细胞癌（OSCCS）中的应用潜力。
材料与方法
对接受颌骨切除术治疗的 OCSCC 患者的新鲜下颌骨切除标本进行拉曼图谱实验。基于水浓度和拉曼光谱的高波数范围（2800cm-3050cm），创建了肿瘤检测算法。
结果
对 22 名患者的 26 个新鲜下颌骨切除标本进行了 26 次离体拉曼图谱实验。该算法在独立测试集中的准确率为 95%，灵敏度为 95%，特异性为 87%。
结论
这些结果为进一步开发拉曼光谱工具作为骨切缘术中评估的客观方法奠定了基础。
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