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四跨膜蛋白阻断可减少外泌体介导的HIV-1进入。

Tetraspanin blockage reduces exosome-mediated HIV-1 entry.

作者信息

Sims Brian, Farrow Anitra L, Williams Sparkle D, Bansal Anju, Krendelchtchikov Alexandre, Matthews Qiana L

机构信息

Division of Neonatology, Departments of Pediatrics, Neurobiology and Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, USA.

Center for AIDS Research, University of Alabama at Birmingham, Birmingham, USA.

出版信息

Arch Virol. 2018 Jun;163(6):1683-1689. doi: 10.1007/s00705-018-3737-6. Epub 2018 Feb 10.

DOI:10.1007/s00705-018-3737-6
PMID:29429034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5958159/
Abstract

HIV-1 is one of the most studied retroviruses. The role of exosomes in HIV-1 entry and pathogenesis are beginning to be appreciated. Exosomes can incorporate host proteins that are also contained in viruses (e.g., tetraspanins).

摘要

人类免疫缺陷病毒1型（HIV-1）是研究最为深入的逆转录病毒之一。外泌体在HIV-1进入细胞及发病机制中的作用正逐渐受到重视。外泌体可以纳入病毒中也含有的宿主蛋白（例如，四跨膜蛋白）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/649b3caf5e48/705_2018_3737_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/f8784e800ae6/705_2018_3737_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/9e114aa2c0e1/705_2018_3737_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/3cfb118ae555/705_2018_3737_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/649b3caf5e48/705_2018_3737_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/f8784e800ae6/705_2018_3737_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/9e114aa2c0e1/705_2018_3737_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/3cfb118ae555/705_2018_3737_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd9/5958159/649b3caf5e48/705_2018_3737_Fig4_HTML.jpg

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