Section of Intercellular Interactions, Eunice-Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Sci Rep. 2017 May 10;7(1):1695. doi: 10.1038/s41598-017-01739-8.
Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy.
被 HIV-1 有效感染的细胞会释放携带包膜糖蛋白 120（Env）的细胞外囊泡（EVs），Env 是一种介导病毒与靶细胞附着和融合的病毒蛋白，也以各种间接方式促进 HIV 感染。去除 EVs（特别是携带 Env 的 EVs）的病毒制剂会降低 HIV 对人淋巴组织的体外感染。因此，我们在研究中发现的携带 Env 的 EVs 似乎促进了 HIV 感染，因此可能成为抗病毒策略的新治疗靶点。
