Ba Rui-Hua, Mao Jian
Second Department of Neonatology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Feb;20(2):83-90. doi: 10.7499/j.issn.1008-8830.2018.02.001.
To investigate the correlation between magnetic resonance imaging (MRI) score and clinical grading in neonatal hypoxic-ischemic encephalopathy (HIE).
Clinical grading was performed for 61 neonates with HIE according to the HIE clinical grading standard. The modified MRI scoring system was used to determine the injury scores on different MRI sequences. The correlation between HIE imaging score and clinical severity was analyzed.
The MRI score in neonates with moderate HIE was significantly lower than that in those with severe HIE (P<0.01). Neonates aged 0-7 days had the highest correlation coefficient between diffusion weighted imaging (DWI) score and total MRI score (r>0.9), and neonates aged >7 days had the highest correlation coefficient between T1-weighted imaging score and total MRI score (r=0.963). Brain MRI showed injuries in the basal ganglia/thalamus+brainstem and even the whole brain in neonates with severe HIE, while the neonates with moderate HIE had injuries in the cerebral watershed, with little involvement of the brainstem (P<0.01).
There is a good correlation between the MRI scoring system and clinical grading in neonatal HIE, suggesting the system can help with the clinical diagnosis and grading of HIE.
探讨新生儿缺氧缺血性脑病（HIE）磁共振成像（MRI）评分与临床分度之间的相关性。
按照HIE临床分度标准对61例HIE新生儿进行临床分度。采用改良的MRI评分系统确定不同MRI序列上的损伤评分。分析HIE影像学评分与临床严重程度之间的相关性。
中度HIE新生儿的MRI评分显著低于重度HIE新生儿（P<0.01）。0至7日龄新生儿的扩散加权成像（DWI）评分与总MRI评分之间的相关系数最高（r>0.9），而大于7日龄新生儿的T1加权成像评分与总MRI评分之间的相关系数最高（r=0.963）。脑MRI显示，重度HIE新生儿的基底节/丘脑+脑干甚至全脑均有损伤，而中度HIE新生儿的脑分水岭区有损伤，脑干受累较少（P<0.01）。
MRI评分系统与新生儿HIE的临床分度之间具有良好的相关性，提示该系统有助于HIE的临床诊断和分度。
