Department of Neurology, Harvard Medical School, Children's Hospital Boston, Boston, MA 02115, USA.
Ann Neurol. 2012 Aug;72(2):156-66. doi: 10.1002/ana.23647.
This Point of View article addresses neonatal encephalopathy (NE) presumably caused by hypoxia-ischemia and the terminology currently in wide use for this disorder. The nonspecific term NE is commonly utilized for those infants with the clinical and imaging characteristics of neonatal hypoxic-ischemic encephalopathy (HIE). Multiple magnetic resonance imaging studies of term infants with the clinical setting of presumed hypoxia-ischemia near the time of delivery have delineated a topography of lesions highly correlated with that defined by human neuropathology and by animal models, including primate models, of hypoxia-ischemia. These imaging findings, coupled with clinical features consistent with perinatal hypoxic-ischemic insult(s), warrant the specific designation of neonatal HIE.
这篇观点文章讨论了可能由缺氧缺血引起的新生儿脑病(NE)以及目前对此疾病广泛使用的术语。术语 NE 通常用于那些具有新生儿缺氧缺血性脑病(HIE)临床和影像学特征的婴儿。在分娩时疑似缺氧缺血的足月婴儿的多项磁共振成像研究已经描绘出与人类神经病理学和缺氧缺血动物模型(包括灵长类动物模型)定义的病变图谱高度相关的病变图谱。这些影像学发现,加上与围产期缺氧缺血损伤一致的临床特征,需要明确指定新生儿 HIE。