给予心房利钠因子后因血压降低引起的交感神经放电可能会抵消其利钠作用。

The blood pressure decrease-induced sympathetic discharge following atrial natriuretic factor administration may offset its natriuretic action.

作者信息

Kuchel O, Garcia R, Debinski W, Racz K, Buu N T, Cantin M, Genest J

出版信息

Proc Soc Exp Biol Med. 1986 Sep;182(4):570-5. doi: 10.3181/00379727-182-4-rc4.

Abstract

Conscious SHR and WKY rats were infused during 7 days with ANF (Arg 101-Tyr 126), 100 ng/hr/rat, by means of miniosmotic pumps and their basal blood pressure (BP), changes in sodium excretion and urinary catecholamines compared with those at the last day of the infusion. The SHR initial BP of 181 +/- 3 mmHg gradually declined to 137 +/- 5 mmHg. No significant change in blood pressure was observed in the ANF-infused WKY group. However, WKY rats exhibited an increased sodium excretion and urinary dopamine/norepinephrine ratio when compared to sham-infused rats. No such differences were observed in SHR. It is suggested that an ANF-induced withdrawal of the renal sympathetic tone permits the manifestation of its natriuretic action in WKY rats. When, however, a BP decrease predominates, as in SHR, this decrease results in a reflex sympathetic discharge with a renal sympathetic activity over-riding the ANF induced natriuresis seen in WKY rats. Secondary sympathetic responses to the ANF-induced BP decrease have to be thus taken into account when a dissociation between the hypotensive and natriuretic action of ANF is observed in vivo.

摘要

清醒的自发性高血压大鼠（SHR）和正常血压大鼠（WKY）通过微型渗透泵持续7天输注心房钠尿肽（ANF，精氨酸101 - 酪氨酸126），剂量为100 ng/小时/只，并将其基础血压（BP）、钠排泄变化和尿儿茶酚胺与输注最后一天的情况进行比较。SHR的初始血压为181±3 mmHg，逐渐降至137±5 mmHg。输注ANF的WKY组未观察到血压有显著变化。然而，与假输注大鼠相比，WKY大鼠的钠排泄增加，尿多巴胺/去甲肾上腺素比值升高。在SHR中未观察到此类差异。提示在WKY大鼠中，ANF诱导的肾交感神经张力降低使其利钠作用得以显现。然而，在SHR中，当血压下降占主导时，这种下降会导致反射性交感神经放电，肾交感神经活动超过了在WKY大鼠中观察到的ANF诱导的利钠作用。因此，当在体内观察到ANF的降压作用和利钠作用分离时，必须考虑对ANF诱导的血压下降的继发性交感反应。