心房利钠因子抑制大鼠单肾单夹高血压模型中的交感神经活动。

Atrial natriuretic factor inhibits the sympathetic nervous activity in one-kidney, one-clip hypertension in the rat.

作者信息

Debinski W, Kuchel O, Garcia R, Nguyen T B, Racz K, Cantin M, Genest J

出版信息

Proc Soc Exp Biol Med. 1986 Jan;181(1):173-7. doi: 10.3181/00379727-181-rc2.

Abstract

The one-kidney, one-clip model of rat hypertension was found to have an increased natriuresis following chronic infusion of atrial natriuretic factor (ANF). We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabolite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio. These data are compatible with the hypothesis that ANF suppresses the increased sympathetic activity in this model of hypertension and this action combined with opposite changes of dopamine may contribute to the natriuretic effect of ANF.

摘要

研究发现，在大鼠高血压的单肾单夹模型中，慢性输注心钠素（ANF）后会出现利钠增加的情况。我们现在发现，ANF的这种利钠作用与最初升高的去甲肾上腺素和肾上腺素尿排泄量的抑制以及主要多巴胺代谢产物二羟基苯乙酸排泄量的增加以及尿多巴胺与去甲肾上腺素比值的增加有关。这些数据与以下假设相符：ANF在该高血压模型中抑制了交感神经活动的增加，并且这种作用与多巴胺的相反变化相结合可能有助于ANF的利钠作用。