Mendelson S D, Gorzalka B B
Physiol Behav. 1986;37(2):345-51. doi: 10.1016/0031-9384(86)90244-1.
The peripheral administration of the serotonin type 1A (5-HT1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH DPAT) inhibited lordosis behavior in ovariectomized rats primed with estradiol benzoate. 8-OH DPAT was ineffective at 0.01 mg/kg, whereas inhibition occurred at the 0.03, 0.1, 0.3, 1, and 3 mg/kg doses. On the other hand, 8-OH DPAT enhanced various measures of male sexual behavior both in males and in females treated chronically with testosterone propionate. In males, 1 mg/kg 8-OH DPAT reduced ejaculation latencies and the number of intromissions prior to ejaculation. In females, 0.1 and 1 mg/kg 8-OH DPAT increased mount frequencies. These data indicate differential involvement of 5-HT1A receptors in male and female sexual behavior. In view of these and other recent data the authors conclude that activity at 5-HT2 receptors facilitates, whereas activity at 5-HT1 receptors may either facilitate or inhibit lordosis behavior. Furthermore, it is proposed that 5-HT1A receptors mediate inhibitory effects, whereas 5-HT1B receptors mediate presynaptic, facilitatory effects of serotonin.
对外周给予血清素1A（5-HT1A）受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH DPAT）可抑制用苯甲酸雌二醇预处理的去卵巢大鼠的脊柱前凸行为。8-OH DPAT在0.01mg/kg时无效，而在0.03、0.1、0.3、1和3mg/kg剂量时会产生抑制作用。另一方面，8-OH DPAT增强了用丙酸睾酮长期处理的雄性和雌性动物的各种雄性性行为指标。在雄性动物中，1mg/kg的8-OH DPAT缩短了射精潜伏期并减少了射精前的插入次数。在雌性动物中，0.1和1mg/kg的8-OH DPAT增加了骑跨频率。这些数据表明5-HT1A受体在雄性和雌性性行为中发挥不同作用。鉴于这些及其他近期数据，作者得出结论：5-HT2受体的活性促进性行为，而5-HT1受体的活性可能促进或抑制脊柱前凸行为。此外，有人提出5-HT1A受体介导抑制作用，而5-HT1B受体介导血清素的突触前促进作用。
