Chemical Engineering Department, Institute of Chemical Technology, Matunga, Mumbai 400019, India.
Chemical Engineering Department, Institute of Chemical Technology, Matunga, Mumbai 400019, India.
Ultrason Sonochem. 2018 Apr;42:347-355. doi: 10.1016/j.ultsonch.2017.11.044. Epub 2017 Dec 2.
Lipids are considered as one of the most crucial nutrients for humans and among the various classes, medium chain triglycerides (MCTs) are considered as the most important functional foods and nutraceuticals. The present work deals with the intensification of synthesis of MCTs at a large capacity of 4L based on the use of ultrasonic bath and ultrasonic longitudinal horn. The effect of operating parameters like molar ratio of the reactants, type of catalyst and catalyst loading as well as the temperature on the extent of conversion has been investigated. The effect of molar ratio of lauric acid and glycerol was investigated over the range of 1:2 to 1:8 whereas the effect of loading of sulfuric acid was studied over the range of 4 ml/L-10 ml/L and zinc chloride loading over the range of 1 g/L-4 g/L. The effect of temperature was also studied using the conventional approach where it has been observed that 90 °C is an optimum temperature giving the extent of conversion as 72%. Also, the use of homogeneous catalyst as sulphuric acid was found to be more effective as compared to the solid catalyst as zinc chloride. It was observed that the maximum extent of conversion as 77.5% was obtained at 8 ml/L of sulfuric acid and molar ratio of 1:6 using ultrasonic longitudinal horn with US bath giving lower conversion as compared to US longitudinal horn but higher than the conventional approach under same operating conditions. The present work clearly established the intensification benefits in terms of reduction in time and higher conversion using cavitational reactors.
脂质被认为是人类最重要的营养物质之一，在各种类别中，中链甘油三酯（MCT）被认为是最重要的功能性食品和营养保健品。本工作基于超声浴和超声纵向换能器的使用，在 4L 的大容量下对 MCT 的合成进行了强化。研究了操作参数（如反应物的摩尔比、催化剂的类型和催化剂负载以及温度）对转化率的影响。考察了月桂酸和甘油的摩尔比对转化率的影响，范围为 1:2 至 1:8，硫酸的负载量为 4 ml/L-10 ml/L，氯化锌的负载量为 1 g/L-4 g/L。还研究了温度的影响，采用传统方法观察到 90°C 是最佳温度，转化率为 72%。此外，与固体催化剂氯化锌相比，硫酸作为均相催化剂的效果更为显著。结果表明，在超声纵向换能器中，当硫酸用量为 8 ml/L，摩尔比为 1:6 时，转化率最高可达 77.5%，超声浴的转化率低于超声纵向换能器，但高于相同操作条件下的传统方法。本工作清楚地证实了在使用空化反应器时，在时间缩短和转化率提高方面的强化效果。
