School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Biomaterials. 2018 Sep;178:738-750. doi: 10.1016/j.biomaterials.2018.01.051. Epub 2018 Feb 3.
As a novel kind of polymer with covalently linked core-shell structure, star polymers behave in nanostructure in aqueous medium at all concentration range, as unimolecular micelles at high dilution condition and multi-micelle aggregates in other situations. The unique morphologies endow star polymers with excellent stability and functions, making them a promising platform for bio-application. A variety of functions including imaging and therapeutics can be achieved through rational structure design of star polymers, and the existence of plentiful end-groups on shell offers the opportunity for further modification. In the last decades, star polymers have become an attracting platform on fabrication of novel nano-systems for bio-imaging and diagnosis. Focusing on the specific topology and physicochemical properties of star polymers, we have reviewed recent development of star polymer-based unimolecular micelles and their bio-application in imaging and diagnosis. The main content of this review summarizes the synthesis of integrated architecture of star polymers and their self-assembly behavior in aqueous medium, focusing especially on the recent advances on their bio-imaging application and diagnosis use. Finally, we conclude with remarks and give some outlooks for further exploration in this field.
作为一种具有共价键连接的核壳结构的新型聚合物，星形聚合物在所有浓度范围内的水溶液中都表现出纳米结构，在高稀释条件下为单分子胶束，而在其他情况下为多胶束聚集体。独特的形态赋予星形聚合物优异的稳定性和功能，使它们成为生物应用的有前途的平台。通过对星形聚合物的合理结构设计，可以实现多种功能，包括成像和治疗，并且壳上存在丰富的端基为进一步修饰提供了机会。在过去的几十年中，星形聚合物已成为用于生物成像和诊断的新型纳米系统的新型平台。本综述重点关注星形聚合物的特定拓扑和物理化学性质，综述了基于星形聚合物的单分子胶束及其在成像和诊断中的生物应用的最新进展。综述的主要内容总结了星形聚合物的整体结构的合成及其在水溶液中的自组装行为，特别关注了它们在生物成像应用和诊断中的最新进展。最后，我们进行了总结并对该领域的进一步探索提出了一些看法。
