癌症干细胞与不断发展的新型疗法：范式转变
Cancer stem cells and evolving novel therapies: a paradigm shift.
作者信息
Naveen Sangeetha Vasudevaraj, Kalaivani Kumar
机构信息
GLR Laboratories Private Limited, Mathur, Chennai, India.
出版信息
Stem Cell Investig. 2018 Jan 23;5:4. doi: 10.21037/sci.2018.01.03. eCollection 2018.
Abstract
Accumulating evidence of stem-like cells/cancer stem cells (CSCs) has been gaining attention of cancer researchers over the last decade. Though many tumors harbor CSCs in their dedicated niches, identifying and exterminating those cells has proved to be difficult, due to their heterogenous nature, as the CSC phenotype vary substantially and may undergo reversible phenotypic changes. As a tumor propagation initiator, CSCs are considered as an exciting novel therapy for a better therapeutic outcome. This review discusses the major advances in the development of CSC-based therapies of most common cancers which includes lung, cervix and liver cancers.
摘要
在过去十年中，关于干细胞样细胞/癌症干细胞（CSCs）的证据不断积累，这引起了癌症研究人员的关注。尽管许多肿瘤在其特定的微环境中含有癌症干细胞，但由于这些细胞具有异质性，其癌症干细胞表型差异很大且可能发生可逆的表型变化，因此识别和消灭这些细胞已被证明是困难的。作为肿瘤增殖的启动者，癌症干细胞被认为是一种有望实现更好治疗效果的新型疗法。本综述讨论了基于癌症干细胞的疗法在最常见癌症（包括肺癌、宫颈癌和肝癌）治疗方面取得的主要进展。
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2
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