UMR Transfrontalière BioEcoAgro1158, Univ. Lille, INRAE, Univ. Liège, UPJV, YNCREA, Univ. Artois, Univ. Littoral Côte d'Opale, ICV-Institut Charles Viollette, 59000 Lille, France.
Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France. UMR 8520-IEMN, 59000 Lille, France.
Int J Environ Res Public Health. 2020 Oct 26;17(21):7835. doi: 10.3390/ijerph17217835.
Bacteriocins are antimicrobial peptides some of which are endowed with antiviral, anticancer and antibiofilm properties. These properties could be improved through synergistic interactions of these bacteriocins with other bioactive molecules such as antibiotics, phages, nanoparticles and essential oils. A number of studies are steadily reporting the effects of these combinations as new and potential therapeutic strategies in the future, as they may offer many incentives over existing therapies. In particular, bacteriocins can benefit from combination with nanoparticles which can improve their stability and solubility, and protect them from enzymatic degradation, reduce their interactions with other molecules and improve their bioavailability. Furthermore, the combination of bacteriocins with other antimicrobials is foreseen as a way to reduce the development of antibiotic resistance due to the involvement of several modes of action. Another relevant advantage of these synergistic combinations is that it decreases the concentration of each antimicrobial component, thereby reducing their side effects such as their toxicity. In addition, combination can extend the utility of bacteriocins as antiviral or anticancer agents. Thus, in this review, we report and discuss the synergistic effects of bacteriocin combinations as medicines, and also for other diverse applications including, antiviral, antispoilage, anticancer and antibiofilms.
细菌素是具有抗病毒、抗癌和抗生物膜特性的抗菌肽，这些特性可以通过这些细菌素与抗生素、噬菌体、纳米粒子和精油等其他生物活性分子的协同相互作用来提高。越来越多的研究报告称，这些组合作为未来新的潜在治疗策略具有许多优势，因为它们可能提供比现有治疗方法更多的激励。特别是，细菌素可以受益于与纳米粒子的组合，这可以提高它们的稳定性和溶解度，并保护它们免受酶降解，减少它们与其他分子的相互作用并提高它们的生物利用度。此外，由于涉及多种作用模式，细菌素与其他抗菌剂的组合被认为是减少抗生素耐药性发展的一种方法。这些协同组合的另一个相关优势是，它降低了每种抗菌成分的浓度，从而降低了它们的副作用，如毒性。此外，组合可以扩展细菌素作为抗病毒或抗癌剂的用途。因此，在这篇综述中，我们报告和讨论了细菌素组合作为药物的协同作用，以及在抗病毒、抗腐败、抗癌和抗生物膜等其他各种应用中的协同作用。
