Zhou Chun-Ni, Xie Hao-Hao, Zheng Zi-Ang, Xiao Yuan-Chao, Li Gen, Shen Yang-Huan, Peng Wang-Ming, Wang Liang
Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, School of Chemical, Environmental Engineering, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.
Chemistry. 2018 Apr 11;24(21):5469-5473. doi: 10.1002/chem.201706025. Epub 2018 Mar 23.
An efficient Rh -catalyzed direct C2-alkenylation of indoles using readily available potassium vinyltrifluoroborate under mild conditions has been developed. This protocol features wide substrate scope and excellent functional group compatibility, enabling a facile access to diverse terminal vinylindoles in moderate to good yields. Furthermore, the C2-alkenylated indole can be easily transformed into 9H-carbazole through a ring-closing metathesis/aromatization cascade.
已开发出一种高效的铑催化吲哚直接C2-烯基化反应，该反应在温和条件下使用易于获得的乙烯基三氟硼酸钾。该方法具有底物范围广和官能团兼容性优异的特点，能够以中等至良好的产率轻松获得各种末端乙烯基吲哚。此外，通过闭环复分解/芳构化级联反应，C2-烯基化吲哚可以很容易地转化为9H-咔唑。
