铑催化的双重不对称 C-H 烯丙基化-环化/硫代反应构建噻苯并呋喃。
Rhodium-Catalyzed Twofold Unsymmetrical C-H Alkenylation-Annulation/Thiolation Reaction To Access Thiobenzofurans.
机构信息
Center for Supramolecular Chemistry & Catalysis and Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
Org Lett. 2021 Feb 19;23(4):1194-1198. doi: 10.1021/acs.orglett.0c04134. Epub 2021 Feb 1.
PMID:33523667
Abstract
A Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/thiolation reaction has been developed, enabling the straightforward and efficient synthesis of various thiobenzofurans in one step. This robust protocol proceeds with a broad substrate scope and good functional group tolerance under relatively mild reaction conditions.
摘要
发展了一种 Rh(III)催化的不对称 C-H 双烯丙基化-环化/硫代反应，可一步高效合成各种噻苯并呋喃。该方法具有广泛的底物适用性和良好的官能团耐受性，反应条件温和。
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