Masnavieva L B, Efimova N V, Kudaeva I V
Gig Sanit. 2016;95(8):738-42.
The high levels of the air pollution create prerequisites for the development of the pathology of target organs exposed to chemical agents. Big enterprises of oil refining and chemical industry of the Irkutsk region are located in the cities of Angarsk and Sayansk. The average level of the air pollution for several years in these cities is assessed as high and moderate, respectively. The use of the personalized approach may allow to more correctly evaluate the risk for the damage to health and the body’s response to external impacts. The purpose of this study was to assess the risk offormation ofpathological processes in the body of adolescents in the conditions of inhalation exposure to chemicals, taking into account the individual load and study of the level of specific autoantibodies. The study included 373 adolescents from the city with high levels of air pollution and 188 schoolchildren from the city with a moderate level pollution. There was made an evaluation of the individual chemical hazard load on adolescents ’ body due to the air pollution, physiologicalfeatures and the organization of educational process and leisure. There were studied the levels of specific autoantibodies, reflecting the state of the organs - targets for the impact ofpollutants. The calculation of the individual chemical load allows to calculate indices of the hazard for the health problems of each individual and to identify individuals at increased risk of developing diseases of organs and systems, which are targets for exposure to pollutants. The increase in the hazard index of developing respiratory diseases was found to be accompanied by an increase of the relative content of autoantibodies against membrane antigens of the lung tissue. There was revealed the elevation in autoantibodies levels to the proteins of vascular endothelial with increasing hazard index of disturbances in the cardiovascular system in adolescents living in city with high levels of air pollution.
高水平的空气污染为接触化学物质的靶器官病理发展创造了前提条件。伊尔库茨克地区的大型炼油和化工企业位于安加尔斯克市和萨扬斯克市。这些城市多年来的空气污染平均水平分别被评估为高和中。采用个性化方法可能有助于更准确地评估健康损害风险以及身体对外部影响的反应。本研究的目的是在考虑个体负荷并研究特定自身抗体水平的情况下，评估青少年在吸入化学物质暴露条件下身体发生病理过程的风险。该研究包括来自空气污染水平高的城市的373名青少年和来自污染水平中等的城市的188名学童。对空气污染、生理特征以及教育过程和休闲活动组织对青少年身体造成的个体化学危害负荷进行了评估。研究了反映污染物作用靶器官状态的特定自身抗体水平。计算个体化学负荷有助于计算每个人健康问题的危害指数，并识别器官和系统疾病发病风险增加的个体，这些器官和系统是污染物的作用靶标。发现患呼吸系统疾病危害指数的增加伴随着针对肺组织膜抗原的自身抗体相对含量的增加。在空气污染水平高的城市生活的青少年中，随着心血管系统紊乱危害指数的增加，发现针对血管内皮蛋白的自身抗体水平升高。
