Berkley S F, Hightower A W, Beier R C, Fleming D W, Brokopp C D, Ivie G W, Broome C V
Ann Intern Med. 1986 Sep;105(3):351-5. doi: 10.7326/0003-4819-105-3-351.
A vesicular, peeling rash characteristic of a phytophototoxic dermatitis developed on the hands and arms of 30 of 127 grocery workers. The rash subsequently healed with residual hyperpigmentation. Produce workers had the highest attack rate, 100% (8 of 8, p less than 0.0001). Although contact with celery had the highest relative risk for disease (relative risk, 6.3; 95% confidence interval, 2.6, 19.2) and the strongest dose-response effect, an association with celery alone could not be shown because workers were also exposed to other produce. However, anecdotal evidence also suggested that celery might be involved. The disease-resistant, high-quality brand of celery carried by these stores had higher levels of furanocoumarins, potent photosensitizers and a known cause of phytophotodermatitis, than other brands (p = 0.01). A randomly selected nationwide sample of stores in this chain showed dermatitis in 13 of 17 states and 26% of produce workers surveyed. Plant breeding to produce a more disease-resistant celery stock may lead to increased levels of endogenous furanocoumarins, resulting in phytophotodermatitis in grocery workers.
127名食品杂货店工人中，有30人手上和手臂出现了具有植物光毒性皮炎特征的水疱性脱皮皮疹。皮疹随后愈合，留下色素沉着。农产品工人的发病率最高，为100%（8例中的8例，p<0.0001）。虽然接触芹菜患该病的相对风险最高（相对风险为6.3；95%置信区间为2.6,19.2），且剂量反应效应最强，但由于工人也接触其他农产品，所以无法证明仅与芹菜有关。然而，轶事证据也表明芹菜可能与此有关。这些商店所售的抗病、高品质品牌芹菜比其他品牌含有更高水平的呋喃香豆素，呋喃香豆素是强效光敏剂，也是已知的植物光毒性皮炎病因（p=0.01）。在该连锁店全国随机抽取的样本中，17个州中有13个州以及26%的受访农产品工人出现了皮炎。培育抗病性更强的芹菜品种可能会导致内源性呋喃香豆素水平升高，从而使食品杂货店工人患上植物光毒性皮炎。
