心房利钠因子对离体大鼠肾小球前列腺素和肾素释放缺乏直接调节作用。

Lack of a direct regulatory effect of atrial natriuretic factor on prostaglandins and renin release by isolated rat glomeruli.

作者信息

Rodríguez-Puyol D, Arriba G, Blanchart A, Santos J C, Caramelo C, Fernández-Cruz A, Hernando L, López-Novoa J M

出版信息

Biochem Biophys Res Commun. 1986 Jul 16;138(1):496-501. doi: 10.1016/0006-291x(86)90308-6.

Abstract

We have tested the direct regulatory effect of synthetic Atrial Natriuretic Peptide (ANP, 8-33aa) on prostaglandins and renin release by isolated rat glomeruli. Variable incubation times and doses of ANP did not modify the rate of PGE2, PGF2a and TXB2 production. Similar results were obtained for renin release. These data do not support a role for ANP in the regulation of prostaglandins and renin release by rat glomeruli.

摘要

我们已经测试了合成心房利钠肽（ANP，8 - 33氨基酸）对离体大鼠肾小球前列腺素和肾素释放的直接调节作用。不同的孵育时间和ANP剂量并未改变前列腺素E2、前列腺素F2α和血栓素B2的生成速率。肾素释放也得到了类似结果。这些数据不支持ANP在调节大鼠肾小球前列腺素和肾素释放中发挥作用。