亚砷酸钠和叠氮化物对悬浮大鼠肝细胞中去唾液酸糖蛋白受体介导的内吞作用的抑制效应
Inhibitory effect of sodium arsenite and azide on asialoglycoprotein receptor mediated endocytosis in suspended rat hepatocytes.
作者信息
Scarmato P, Durand G, Agneray J, Feger J
出版信息
Biol Cell. 1986;56(3):255-8. doi: 10.1111/j.1768-322x.1986.tb00457.x.
The inhibitory effect of sodium arsenite and azide on asialoorosomucoid endocytosis was tested using isolated rat hepatocytes. Under either continuous flux conditions or a single synchronous wave of ligand endocytosis we confirm that azide inhibits the recycling of the receptors and we provide evidence for the involvement of thiol groups in the internalization step. In addition pretreatment of hepatocytes with azide allows us to demonstrate that receptor endocytosis proceeds independently of the presence of any specific ligand.
利用分离的大鼠肝细胞测试了亚砷酸钠和叠氮化物对去唾液酸糖蛋白内吞作用的抑制效果。在连续通量条件或单次同步配体内吞波条件下，我们证实叠氮化物会抑制受体的再循环，并且我们提供了巯基参与内化步骤的证据。此外，用叠氮化物对肝细胞进行预处理使我们能够证明受体的内吞作用独立于任何特定配体的存在而进行。
Zotero 插件