空肠回肠旁路大鼠肝细胞对去唾液酸血清类黏蛋白的内吞作用及结合
Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass.
作者信息
Serbource-Goguel/Seta N, Borel B, Dodeur M, Scarmato P, Bourel B, Feger J, Durand G
出版信息
Hepatology. 1985 Mar-Apr;5(2):220-3. doi: 10.1002/hep.1840050211.
Rats with jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoorosomucoid in serum has been determined. Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomucoid by bypassed rat hepatocytes was decreased by about 60%. This was due to a decreased number of total and surface receptors. In most sera, an accumulation of asialoorosomucoid was found. A reduction of protein synthesis or turnover could be considered.
采用空肠回肠旁路大鼠来研究肝脏结合蛋白的生物活性。在手术操作11周后制备肝细胞，并测定血清中去唾液酸糖蛋白的存在情况。与对照大鼠肝细胞相比，旁路大鼠肝细胞对[3H]去唾液酸糖蛋白的内吞作用降低了约60%。这是由于总受体和表面受体数量减少所致。在大多数血清中，发现去唾液酸糖蛋白有蓄积。可以考虑蛋白质合成或周转的减少。
Zotero 插件