Department of Biomedical Sciences, Iowa State University, Ames, IA 50010, USA.
Department of Biomedical Sciences, Iowa State University, Ames, IA 50010, USA.
Trends Parasitol. 2018 Apr;34(4):263-265. doi: 10.1016/j.pt.2018.01.006. Epub 2018 Feb 9.
Chan et al. recently demonstrated that the antischistosomal drug praziquantel has a potent and specific interaction with human 5-HT receptors, and that the drug also elicits contraction of mouse mesenteric vasculature apparently mediated by the same receptor subtype We consider what this might mean about the drug's molecular therapeutic targets in both the worm and the host.
陈等人最近表明，抗血吸虫药物吡喹酮与人 5-HT 受体具有强大而特异的相互作用，而且该药物还引起小鼠肠系膜血管收缩，显然是通过相同的受体亚型介导的。我们考虑这可能意味着该药物在蠕虫和宿主中的分子治疗靶点。
