Department of Public and Occupational Health, Amsterdam Public Health Research Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark.
Int J Cardiol. 2018 May 1;258:109-114. doi: 10.1016/j.ijcard.2018.01.089. Epub 2018 Feb 9.
Imbalance in the autonomic nervous system due to a disrupted circadian rhythm may be a cause of shift work-related cardiovascular diseases.
We aimed to determine the association between shift work and cardiac autonomic activity in blue-collar workers.
The study included 665 blue-collar workers aged 18-68 years in different occupations from two Danish cohort studies. Time and frequency domain parameters of heart rate variability (HRV) were measured during sleep using the Actiheart monitor, and used as markers of cardiac autonomic function. Multiple linear regression analyses were used to investigate differences in HRV between day and shift workers.
Shift workers had no significantly different HRV parameters than day workers, except for a lower VLF (B: 0.21; 95% CI: -0.36-0.05). The lower VLF was only present among non-night shift workers (p < 0.05) and not among night shift workers (p > 0.05). Results differed significantly by gender (p for interaction < 0.10): among men, shift work was negatively associated with RMSSD (B: -7.83; 95% CI: -14.28-1.38), SDNN (B: -7.0; 95% CI: -12.27-1.78), VLF (B: -0.27; 95% CI: -0.46-0.09) and Total Power (B: -0.61; 95% CI: -1.20-0.03), while among women, shift work was only associated with the LF/HF ratio (B: -0.29; 95% CI: -0.54-0.03).
Shift work was particularly associated with lower HRV during sleep among men. This indicates that shift work causes imbalance in the autonomic nervous system among men, which might increase their risk of cardiovascular diseases.
由于昼夜节律紊乱导致的自主神经系统失衡可能是轮班工作相关心血管疾病的一个原因。
我们旨在确定轮班工作与蓝领工人心脏自主活动之间的关系。
这项研究纳入了来自丹麦两项队列研究的 665 名年龄在 18-68 岁之间从事不同职业的蓝领工人。使用 Actiheart 监测仪在睡眠期间测量心率变异性（HRV）的时频域参数，作为心脏自主功能的标志物。使用多元线性回归分析来研究日间工作者和轮班工作者之间 HRV 的差异。
轮班工作者的 HRV 参数与日间工作者没有显著差异，除了 VLF 较低（B：0.21；95%CI：-0.36-0.05）。这种较低的 VLF 仅存在于非夜班工作者中（p<0.05），而不存在于夜班工作者中（p>0.05）。结果在性别上存在显著差异（p 交互<0.10）：在男性中，轮班工作与 RMSSD（B：-7.83；95%CI：-14.28-1.38）、SDNN（B：-7.0；95%CI：-12.27-1.78）、VLF（B：-0.27；95%CI：-0.46-0.09）和总功率（B：-0.61；95%CI：-1.20-0.03）呈负相关，而在女性中，轮班工作仅与 LF/HF 比值相关（B：-0.29；95%CI：-0.54-0.03）。
轮班工作尤其与男性睡眠期间 HRV 降低有关。这表明轮班工作会导致男性自主神经系统失衡，从而增加他们患心血管疾病的风险。
