Wang Junrong, Wang Wei, Guo Wei, Ma Yanru, Ji Tianhui, Zhang Baodi
Operating Room, First Branch of Mudanjiang Medical University Affiliated Hongqi Hospital, Mudanjiang, Heilongjiang 157011, P.R. China.
Department of Opthalmology, Mudanjiang Medical University Affiliated Hongqi Hospital, Mudanjiang, Heilongjiang 157011, P.R. China.
Exp Ther Med. 2018 Feb;15(2):2189-2195. doi: 10.3892/etm.2017.5645. Epub 2017 Dec 15.
Chemokines are a class of proteins with low molecular weight that serve important roles in the progression of inflammation. Percutaneous nephrolithotripsy is a surgical technique in which lasers or ultrasound are utilized to break down and/or remove kidney stones. In order to ensure a full recovery following surgery, effective patient care and nursing are required. In the present study, a total of 348 patients with kidney stones were recruited and the clinical importance of chemokines and inflammatory cytokines for the nursing of patients during perioperative period was investigated. Plasma levels of inflammatory cytokines, as well as chemokines in the C, CC and CXC families, were analyzed in patients following percutaneous nephrolithotripsy. Correlations between chemokines and inflammatory cytokines and the urinary concentration of calcium oxalate were also investigated. The results indicated that plasma levels of C and CC chemokines were downregulated in patients following percutaneous nephrolithotripsy, whereas the plasma concentrations of CXC chemokines were upregulated. Plasma concentration levels of inflammatory cytokines interleukin (IL)-8, IL-1, IL-17 and tumor necrosis factor (TNF)-α were significantly downregulated in patients following percutaneous nephrolithotripsy; however, no significant differences were observed in plasma levels of IL-6 and IL-10 pre- and post-surgery. Regression analysis revealed that plasma concentration levels of chemokine C motif ligand, which is a C chemokine, chemokine ligand 2, which is a CC chemokine, and TNF-α were positively correlated with the urinary concentration of calcium oxalate during the perioperative period. The results of the present study indicate that plasma levels of chemokines and inflammatory cytokines are clinically important for nursing of patients who experienced percutaneous nephrolithotripsy.
趋化因子是一类低分子量蛋白质，在炎症进展中发挥重要作用。经皮肾镜碎石术是一种外科技术，利用激光或超声波来分解和/或清除肾结石。为确保术后完全康复，需要有效的患者护理。在本研究中，共招募了348例肾结石患者，并研究了趋化因子和炎性细胞因子在围手术期对患者护理的临床重要性。分析了经皮肾镜碎石术后患者血浆中炎性细胞因子以及C、CC和CXC家族趋化因子的水平。还研究了趋化因子与炎性细胞因子以及草酸钙尿浓度之间的相关性。结果表明，经皮肾镜碎石术后患者血浆中C和CC趋化因子水平下调，而CXC趋化因子的血浆浓度上调。经皮肾镜碎石术后患者血浆中炎性细胞因子白细胞介素（IL）-8、IL-1、IL-17和肿瘤坏死因子（TNF）-α的浓度水平显著下调；然而，术前和术后血浆中IL-6和IL-10水平未观察到显著差异。回归分析显示，围手术期C趋化因子趋化因子C基序配体、CC趋化因子趋化因子配体2和TNF-α的血浆浓度水平与草酸钙尿浓度呈正相关。本研究结果表明，趋化因子和炎性细胞因子的血浆水平对经历经皮肾镜碎石术的患者护理具有临床重要性。
