湿润暴露烧伤膏治疗压疮：一项多中心随机对照试验。

Moist exposed burn ointment for treating pressure ulcers: A multicenter randomized controlled trial.

作者信息

Li Wei, Ma Yubo, Yang Qi, Pan Yu, Meng Qinggang

机构信息

Department of Medical Science Institute of Harbin, the First Hospital of Harbin, Harbin Medical University, Harbin Department of Orthopedics, Hongqi Hospital of Mudanjiang Medical College, Mudanjiang Department of Study Center, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

出版信息

Medicine (Baltimore). 2017 Jul;96(29):e7582. doi: 10.1097/MD.0000000000007582.

DOI:10.1097/MD.0000000000007582

PMID:28723796

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5521936/

Abstract

BACKGROUND

Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients.

METHODS

Seventy-two patients with pressure ulcers were randomly assigned to 2 groups who received a placebo or MEBO for 2 months. The primary outcomes included the wound surface area (WSA) and pressure ulcer scale for healing (PUSH) tool. The secondary outcomes included a visual analog scale (VAS), questionnaire of ulcer status, and adverse effects.

RESULTS

Sixty-seven patients completed the study. After 2 months of treatment, the difference of mean change from the baseline was greater for MEBO (vs placebo) for WSA mean (SD) -6.0 (-8.8, -3.3), PUSH Tool -2.6 (-4.7, -1.5), and VAS score -2.9 (-4.4, -1.7). On the basis of the questionnaire, the pressure ulcers were "completely healed" (50.0% vs 16.7%) (P < .05) in patients after 2 months of treatment with MEBO versus placebo. No major adverse effects were found in the 2 groups.

CONCLUSION

We showed that MEBO is effective and well tolerated for improving wound healing in Chinese patients with pressure ulcers.

摘要

背景

压疮常严重影响患者生活质量。湿润烧伤膏（MEBO）已被用于治疗压疮患者。本研究旨在评估MEBO治疗中国压疮患者的疗效和安全性。

方法

72例压疮患者被随机分为两组，分别接受安慰剂或MEBO治疗2个月。主要结局指标包括创面面积（WSA）和压疮愈合量表（PUSH）工具。次要结局指标包括视觉模拟量表（VAS）、溃疡状况问卷和不良反应。

结果

67例患者完成研究。治疗2个月后，MEBO组（与安慰剂组相比）WSA均值（标准差）从基线的平均变化差异更大，为-6.0（-8.8，-3.3），PUSH工具为-2.6（-4.7，-1.5），VAS评分为-2.9（-4.4，-1.7）。根据问卷，MEBO治疗2个月后的患者中压疮“完全愈合”的比例为50.0%，而安慰剂组为16.7%（P<0.05）。两组均未发现严重不良反应。