Tang Wenlong, Chen Yupeng, Wang Xingfu, Chen Yao, Zhang Jiandong, Lin Zhixiong
Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.
Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.
Oncol Lett. 2018 Feb;15(2):2501-2507. doi: 10.3892/ol.2017.7547. Epub 2017 Dec 8.
The present study aimed to evaluate the association between CXC-motif-chemokine 12 (CXCL12)/C-X-C receptor 4 (CXCR4) expression and peritumoral brain edema (PTBE) in glioma patients. Immunohistochemical techniques were used to detect the expression of CXCR4 and CXCL12 in 58 glioma tissues. Magnetic resonance imaging was used to evaluate the extent and type of brain edema in preoperative glioma patients. The association between edema and CXCL12/CXCR4 expression was examined by χ analysis. The prognostic significance of CXCL12 or CXCR4 was determined by log-rank tests and Cox's proportional hazards model. Expression of CXCL12 and CXCR4 was observed in vascular endothelial cells and tumor cells. The degree (P0.033) and morphology (P0.033) of PTBE were significantly associated with the level of CXCL12 expression in vascular endothelial cells. The degree (P0.001) and morphology (P0.001) of PTBE were associated with the level of CXCR4 expression in tumor cells. CXCR4-positive vascular endothelial cells were significantly associated only with the degree of edema (P0.030). Therefore, the present study indicated that levels of CXCL12 expression in vascular endothelial cells and CXCR4 expression in tumor cells are associated with PTBE.
本研究旨在评估胶质瘤患者中CXC趋化因子12（CXCL12）/C-X-C趋化因子受体4（CXCR4）表达与瘤周脑水肿（PTBE）之间的关联。采用免疫组织化学技术检测58例胶质瘤组织中CXCR4和CXCL12的表达。利用磁共振成像评估术前胶质瘤患者脑水肿的程度和类型。通过χ分析检测水肿与CXCL12/CXCR4表达之间的关联。采用对数秩检验和Cox比例风险模型确定CXCL12或CXCR4的预后意义。在血管内皮细胞和肿瘤细胞中观察到CXCL12和CXCR4的表达。PTBE的程度（P<0.033）和形态（P<0.033）与血管内皮细胞中CXCL12的表达水平显著相关。PTBE的程度（P<0.001）和形态（P<0.001）与肿瘤细胞中CXCR4的表达水平相关。CXCR4阳性血管内皮细胞仅与水肿程度显著相关（P<0.030）。因此，本研究表明血管内皮细胞中CXCL12的表达水平和肿瘤细胞中CXCR4的表达水平与PTBE相关。
