Villanueva Omar, Weldy Nina Mace, Blakey Simon B, MacBeth Cora E
Department of Chemistry , Emory University , USA . Email:
Chem Sci. 2015 Nov 1;6(11):6672-6675. doi: 10.1039/c5sc01162k. Epub 2015 Jul 30.
A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C-H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C-H amination technology.
一种由模块化、可调节的氧化还原活性配体体系支撑的双核钴（II）配合物能够在低催化剂负载量（1 mol%）下实现选择性C-H胺化反应，以良好的产率从芳基叠氮化物形成二氢吲哚。该反应对吡啶和吲哚等具有药物相关性的杂环具有耐受性，可用于形成5元、6元和7元环。使用低负载量的储量丰富的过渡金属配合物所获得的合成通用性代表了催化C-H胺化技术的一项重大进展。
