Li Nai-Kai, Fan Wei-Tai, Zhang Jun-Qi, Sun Bing-Bing, Chen Jun-Bo, Wang Xing-Wang
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Chem Commun (Camb). 2018 Feb 27;54(18):2260-2263. doi: 10.1039/c7cc09489b.
A combination of metal- and organo-catalysts sequentially catalyzing the Friedel-Crafts/aldol tandem reaction between 3-pyrrolyl-oxindoles and isatin-derived β,γ-unsaturated α-ketoesters has been reported, which leads to two types of diastereomeric enantio-enriched bispirooxindoles with three quaternary stereocentres and synthetically valuable functional groups in high yields with excellent enantioselectivity and diastereoselectivity.
据报道，金属催化剂和有机催化剂相结合可依次催化3-吡咯基氧化吲哚与异吲哚酮衍生的β,γ-不饱和α-酮酯之间的傅克/羟醛串联反应，该反应能以高收率、优异的对映选择性和非对映选择性得到两种具有三个季碳立体中心和具有合成价值官能团的非对映体对映体富集双螺氧化吲哚。
