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从日本夏橙（Citrus tamurana Hort.）中分离细胞色素P450 3A（CYP3A）抑制剂

Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana Hort.

作者信息

Hosoi Shinzo, Shimizu Eri, Usami Noriyuki, Yamamoto Ikuo, Arimori Kazuhiko, Okumura Manabu, Hidaka Muneaki, Yamada Mitsuko, Sakushima Akiyo

机构信息

School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan.

Department of Pharmacy, Miyazaki Medical College Hospital, 5200 Kihara, Kiyotake-cho, Miyazaki-gun, Miyazaki 889-1692, Japan.

出版信息

J Nat Med. 2006 Jul;60(3):240-242. doi: 10.1007/s11418-006-0031-9. Epub 2006 Apr 14.

DOI:10.1007/s11418-006-0031-9
PMID:29435884
Abstract

The present study was conducted to identify cytochrome P450 3A (CYP3A) inhibitory components of Hyuganatsu, Citrus tamurana Hort., by investigating the effects on midazolam 1'-hydroxylase activity of human liver microsomes. As a consequence, limonin and nomilin were identified as CYP3A inhibitors from the endocarp of Hyuganatsu.

摘要

本研究旨在通过研究对人肝微粒体中咪达唑仑1'-羟化酶活性的影响，鉴定出日向夏（Citrus tamurana Hort.）中的细胞色素P450 3A（CYP3A）抑制成分。结果，从日向夏的内果皮中鉴定出柠檬苦素和诺米林为CYP3A抑制剂。

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Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana Hort.从日本夏橙（Citrus tamurana Hort.）中分离细胞色素P450 3A（CYP3A）抑制剂
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引用本文的文献

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Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics.柠烯：药理学、毒理学和药代动力学综述。
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Revealing the mechanism of in vitro wound healing properties of Citrus tamurana extract.揭示柑橘提取物体外愈合性能的机制。

本文引用的文献

1
Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract.吴茱萸果实提取物中的吴茱萸次碱和柠檬苦素对人肝微粒体CYP3A4的基于机制的失活作用。
Drug Metab Pharmacokinet. 2005 Feb;20(1):34-45. doi: 10.2133/dmpk.20.34.
2
Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.杨桃对人细胞色素P450 3A（CYP3A）活性有强效抑制作用。
Drug Metab Dispos. 2004 Jun;32(6):581-3. doi: 10.1124/dmd.32.6.581.
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柑橘类水果对人体细胞色素P450 3A（CYP3A）活性的抑制作用。
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Grapefruit component interacting with rat and human P450 CYP3A: possible involvement of non-flavonoid components in drug interaction.葡萄柚成分与大鼠和人类细胞色素P450 CYP3A的相互作用：非类黄酮成分可能参与药物相互作用。
Biol Pharm Bull. 1997 May;20(5):560-4. doi: 10.1248/bpb.20.560.
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Clin Pharmacokinet. 1994 Feb;26(2):91-8. doi: 10.2165/00003088-199426020-00002.
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Disposition of intravenous and oral cyclosporine after administration with grapefruit juice.静脉注射和口服环孢素与葡萄柚汁一起给药后的处置情况。
Clin Pharmacol Ther. 1995 May;57(5):485-91. doi: 10.1016/0009-9236(95)90032-2.
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Effect of grapefruit juice on blood cyclosporin concentration.葡萄柚汁对血液中环孢素浓度的影响。
Lancet. 1995 Apr 15;345(8955):955-6. doi: 10.1016/s0140-6736(95)90700-9.
8
Interaction between grapefruit juice and midazolam in humans.葡萄柚汁与咪达唑仑在人体中的相互作用。
Clin Pharmacol Ther. 1995 Jul;58(1):20-8. doi: 10.1016/0009-9236(95)90068-3.