Yee G C, Stanley D L, Pessa L J, Dalla Costa T, Beltz S E, Ruiz J, Lowenthal D T
Department of Pharmacy Practice, College of Pharmacy, University of Florida Health Science Center, Gainesville 32610, USA.
Lancet. 1995 Apr 15;345(8955):955-6. doi: 10.1016/s0140-6736(95)90700-9.
Grapefruit juice increases blood concentrations of some dihydropyridine calcium-channel blockers, which are metabolised by the P450 enzymes that also metabolise cyclosporin. We evaluated, in a randomised cross-over study, the effect of grapefruit juice on blood cyclosporin concentrations in 14 healthy adults. Each subject was given oral cyclosporin 300 mg with 250 mL grapefruit juice, orange juice, or water. Area-under-the-curve (AUC) was significantly higher with grapefruit juice than with water or orange juice (means 7057, 4871, and 4932 ng h/mL, respectively; p < 0.0001). Thus grapefruit juice may provide a non-toxic and inexpensive alternative to drugs that are used to reduce cyclosporin dose.
葡萄柚汁会提高某些二氢吡啶类钙通道阻滞剂的血药浓度，这些阻滞剂由细胞色素P450酶代谢，而该酶也参与环孢素的代谢。在一项随机交叉研究中，我们评估了葡萄柚汁对14名健康成年人血中环孢素浓度的影响。每位受试者口服300毫克环孢素，同时分别饮用250毫升葡萄柚汁、橙汁或水。葡萄柚汁组的曲线下面积（AUC）显著高于水或橙汁组（分别为7057、4871和4932纳克·小时/毫升；p < 0.0001）。因此，葡萄柚汁可能为用于减少环孢素剂量的药物提供一种无毒且廉价的替代方案。
