Division of Gastroenterology, Department of Internal Medicine, TARGID, University Hospital Gasthuisberg, Leuven, Belgium.
Laboratory of Food Chemistry and Biochemistry & Leuven Food Science and Nutrition Research Centre (LFoRCe), Catholic University of Leuven, Leuven, Belgium.
Neurogastroenterol Motil. 2018 Jul;30(7):e13306. doi: 10.1111/nmo.13306. Epub 2018 Feb 13.
Prebiotics such as Arabinoxylooligosaccharides (AXOS) are non-digestible, fermentable food ingredients stimulating growth/activity of colonic bacteria with enhanced carbohydrates fermentation (CF) in humans. The migrating motor complex (MMC) of the gastrointestinal tract has been recently identified as an important hunger signal, but no data are available yet on the role of acute CF on MMC activity and related hunger ratings. Thus, we aimed to study the effect of acute AXOS CF on MMC and hunger in humans.
A total of 13 healthy volunteers were randomized in a single-blind crossover placebo-controlled study where 9.4 g of AXOS or 10 g of maltodextrin and 1 g of unlabelled lactose ureide (LU) were given 12 hours prior to the study and, in the next morning, together with a pancake containing 500 mg of C-LU. In 10 hours after the meal, CO and hydrogen excretion were determined every 15 minutes while hunger/appetite ratings every 2 minutes through a VAS questionnaire. Five hours after the meal, antroduodenal motility was measured using HRM.
AXOS significantly increased CF (158 ± 81 vs 840 ± 464 H2 ppm*minute, placebo vs AXOS, P < .05) without affecting the orocecal transit time (OCTT). AXOS had no significant effect on the occurrence, origin, and duration of phase III and on the total number, origin, and duration of phases I and II. Hunger and appetite scores prior and after phase III were not affected by AXOS.
AXOS acutely increases colonic fermentation, but this neither affects OCTT, activity of the MMC, nor interdigestive hunger scores in man.
诸如阿拉伯木聚糖低聚糖（AXOS）之类的益生元是不可消化的，可发酵的食物成分，可刺激结肠细菌的生长/活性，并增强人类的碳水化合物发酵（CF）。 胃肠道的移行性运动复合波（MMC）最近被确定为重要的饥饿信号，但尚无关于急性 CF 对 MMC 活性和相关饥饿评分的作用的数据。 因此，我们旨在研究急性 AXOS CF 对人类 MMC 和饥饿的影响。
总共 13 名健康志愿者被随机分为单盲交叉安慰剂对照研究，其中 9.4g AXOS 或 10g 麦芽糊精和 1g 未标记的乳尿素（LU）在研究前 12 小时给予，然后在第二天早上与含有 500mg 的 C-LU 的煎饼一起给予。 进餐后 10 小时，每 15 分钟测定一次 CO 和氢气排泄，每 2 分钟通过 VAS 问卷测定一次饥饿/食欲评分。 进餐后 5 小时，使用 HRM 测量胃十二指肠动力。
AXOS 显著增加了 CF（158±81 与 840±464 H2 ppm*min，安慰剂与 AXOS，P<.05），而不影响口盲肠转运时间（OCTT）。 AXOS 对 III 期的发生，起源和持续时间以及 I 期和 II 期的总数，起源和持续时间均无明显影响。 III 期前后的饥饿和食欲评分不受 AXOS 影响。
AXOS 可急性增加结肠发酵，但这既不影响 OCTT，也不影响 MMC 的活动，也不影响人类的消化间饥饿评分。
