Institute for Social Science Research and School of Public Health,The University of Queensland,Brisbane,Australia and Department of Epidemiology and Biostatistics,Institute of Public Health,University of Gondar,Ethiopia.
Institute for Social Science Research and School of Public Health,The University of Queensland,Brisbane,Australia.
Br J Psychiatry. 2018 Mar;212(3):142-147. doi: 10.1192/bjp.2017.27. Epub 2018 Jan 24.
Evidence about the effect of intrauterine exposure to pre-eclampsia on offspring autism-spectrum disorder (ASD) is not well established. Aims To examine the association between pre-eclampsia and ASD.
PubMed, Embase and PsycINFO databases were searched. Pooled relative risks (RR) with 95% confidence intervals were calculated. Subgroup and sensitivity analyses were performed. Heterogeneity was assessed using Cochran's Q- and the I 2-test. The presence of publication bias was evaluated by Egger's test and visual inspection of the symmetry in funnel plots.
Ten studies meet the inclusion criteria. The risk of ASD was 32% higher in offspring who had intrauterine exposure to pre-eclampsia compared with those not exposed (RR = 1.32, 95% CI 1.20-1.45). Sensitivity analysis revealed consistent pooled estimates ranging from RR = 1.30 (95% CI 1.17-1.44) to RR = 1.37 (95% CI 1.26-1.48). We found no significant heterogeneity and evidence of publication bias.
Pre-eclampsia increased the risk of ASD in offspring. The finding suggests a need for early screening for ASD in offspring of women with pre-eclampsia. Declaration of interest None.
关于子痫前期宫内暴露对子代自闭症谱系障碍（ASD）影响的证据尚不清楚。目的：研究子痫前期与 ASD 之间的关系。
检索 PubMed、Embase 和 PsycINFO 数据库。计算合并的相对风险（RR）及其 95%置信区间。进行亚组和敏感性分析。使用 Cochran's Q 检验和漏斗图的对称性来评估异质性。采用 Egger 检验和漏斗图的对称性来评估发表偏倚的存在。
符合纳入标准的研究有 10 项。与未暴露于子痫前期的儿童相比，宫内暴露于子痫前期的儿童 ASD 的风险增加了 32%（RR=1.32，95%CI 1.20-1.45）。敏感性分析显示，合并估计值范围从 RR=1.30（95%CI 1.17-1.44）到 RR=1.37（95%CI 1.26-1.48），均保持一致。未发现显著异质性和发表偏倚的证据。
子痫前期增加了后代 ASD 的风险。这一发现表明，子痫前期妇女的后代需要进行 ASD 的早期筛查。
无。
