自身免疫性NZB小鼠中扩增的T细胞活性及其在自身免疫性疾病表达中的可能意义。
Increased amplifier T cell activity in autoimmune NZB mice and its possible significance in the expression of autoimmune disease.
作者信息
Baker P J, Fauntleroy M B, Stashak P W, McCoy K L, Chused T M
出版信息
Immunobiology. 1986 Jul;171(4-5):400-11. doi: 10.1016/S0171-2985(86)80072-9.
The expression of amplifier- and helper-T cell activity was examined in NZB/N mice of different ages. Amplifier T cell activity develops in a cyclic manner; it decreases between 16 and 35 wk of age and then increases to maximal levels in mice older than 50 wk of age. The loss of suppressor T cell activity and increased amplifier T cell activity coincide with the development of autoimmune diseases in aging NZB/N mice. Although helper T cell activity is evident in young NZB/N mice, it is absent in old NZB/N mice expressing maximal amplifier T cell activity. This provides additional support for the fact that amplifier and helper functions are mediated by different subpopulations of T cells.
在不同年龄的NZB/N小鼠中检测了放大T细胞和辅助性T细胞活性的表达。放大T细胞活性呈周期性发展；在16至35周龄之间降低，然后在50周龄以上的小鼠中增加到最高水平。抑制性T细胞活性的丧失和放大T细胞活性的增加与衰老的NZB/N小鼠自身免疫性疾病的发展相一致。虽然辅助性T细胞活性在年轻的NZB/N小鼠中很明显，但在表达最大放大T细胞活性的老年NZB/N小鼠中却不存在。这为放大功能和辅助功能由不同的T细胞亚群介导这一事实提供了额外的支持。
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