Margaretten N C, Warren R P
Immunol Invest. 1986 Apr;15(2):159-67. doi: 10.3109/08820138609094141.
A number of immune abnormalities have been found in epileptic patients. Several, but not all, of these defects appear to be related to the toxic effects of antiseizure medications. To study the basis of immune abnormalities in epilepsy, various populations and subsets of peripheral blood mononuclear cells (PBMC) from epileptic patients were enumerated and their functions examined. Reduced natural killer cell activity was found in the patients and their siblings. Enumeration of the PBMC showed a lower proportions of Leu 11+ cells in some of the patients which may account for the lower natural killer activity. A reduced ratio of OKT4+/OKT8+ cells was also found in the patients. Responses of patient PBMC to the T-cell mitogens phytohemagglutinin, concanavalin A and the B-cell mitogen pokeweed mitogen were unchanged as were the total number of rosette-forming cells in the patients. The results provide more evidence for a genetic basis for some of the immune abnormalities in epileptic patients.
在癫痫患者中发现了许多免疫异常情况。其中一些（但并非全部）缺陷似乎与抗癫痫药物的毒性作用有关。为了研究癫痫患者免疫异常的基础，对癫痫患者外周血单个核细胞（PBMC）的不同群体和亚群进行了计数，并检测了它们的功能。在患者及其亲属中发现自然杀伤细胞活性降低。PBMC计数显示，部分患者中Leu 11+细胞的比例较低，这可能是自然杀伤活性较低的原因。在患者中还发现OKT4+/OKT8+细胞的比例降低。患者PBMC对T细胞有丝分裂原植物血凝素、刀豆球蛋白A以及B细胞有丝分裂原美洲商陆有丝分裂原的反应未发生变化，患者中玫瑰花结形成细胞的总数也未改变。这些结果为癫痫患者某些免疫异常的遗传基础提供了更多证据。
