Pediatric Neurology and Autism Neurodevelopmental Program, Sutter Neuroscience Institute, Sacramento, California 95816, USA.
Neurotherapeutics. 2010 Jul;7(3):293-301. doi: 10.1016/j.nurt.2010.05.008.
Autism affects 1 in 110 new births, and it has no single etiology with uniform agreement. This has a significant impact on the quality of life for individuals who have been diagnosed with autism. Although autism has a spectrum quality with a shared diagnosis, it presents a uniquely different clinical appearance in each individual. Recent research of suspected immunological factors have provided more support for a probable immunological process or for processes that may play a role in the acquisition of an autistic condition. These factors include prenatal, genetic, and postnatal findings, as well as the discovery of a dysfunctional chronic pro-inflammatory state in brain tissue and cerebrospinal fluid in subsets of autistic patients. These findings offer new theories that may lead to the development of disease modification or preventative therapeutic options in the near future. This article reviews prenatal, genetic, and observed immune aspects of the autism condition that may be risk factors in the presentation of the autistic clinical phenotype. Historical immune interventions in autism are reviewed and potential new therapies and interventions are discussed.
自闭症影响每 110 名新生儿中的 1 名，其病因尚无统一共识，这对被诊断为自闭症的个体的生活质量有重大影响。尽管自闭症具有共享诊断的谱系质量，但在每个个体中呈现出独特的不同临床表象。最近对疑似免疫因素的研究为可能的免疫过程或可能在自闭症发病中起作用的过程提供了更多支持。这些因素包括产前、遗传和产后发现，以及在自闭症患者亚组的脑组织和脑脊液中发现功能失调的慢性炎症状态。这些发现提供了新的理论，可能会在不久的将来导致疾病修饰或预防性治疗选择的发展。本文综述了自闭症的产前、遗传和观察到的免疫方面，这些方面可能是自闭症临床表型表现的风险因素。文中还回顾了自闭症的历史免疫干预，并讨论了潜在的新疗法和干预措施。
