Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Mov Disord. 2018 Apr;33(4):642-646. doi: 10.1002/mds.27300. Epub 2018 Feb 13.
Recent findings suggest that transcranial direct current stimulation of the primary motor cortex may ameliorate freezing of gait. However, the effects of multitarget simultaneous stimulation of motor and cognitive networks are mostly unknown. The objective of this study was to evaluate the effects of multitarget transcranial direct current stimulation of the primary motor cortex and left dorsolateral prefrontal cortex on freezing of gait and related outcomes.
Twenty patients with Parkinson's disease and freezing of gait received 20 minutes of transcranial direct current stimulation on 3 separate visits. Transcranial direct current stimulation targeted the primary motor cortex and left dorsolateral prefrontal cortex simultaneously, primary motor cortex only, or sham stimulation (order randomized and double-blinded assessments). Participants completed a freezing of gait-provoking test, the Timed Up and Go, and the Stroop test before and after each transcranial direct current stimulation session.
Performance on the freezing of gait-provoking test (P = 0.010), Timed Up and Go (P = 0.006), and the Stroop test (P = 0.016) improved after simultaneous stimulation of the primary motor cortex and left dorsolateral prefrontal cortex, but not after primary motor cortex only or sham stimulation.
Transcranial direct current stimulation designed to simultaneously target motor and cognitive regions apparently induces immediate aftereffects in the brain that translate into reduced freezing of gait and improvements in executive function and mobility. © 2018 International Parkinson and Movement Disorder Society.
最近的研究结果表明，经颅直流电刺激初级运动皮层可能改善冻结步态。然而，运动和认知网络的多靶点同步刺激的效果大多尚不清楚。本研究的目的是评估经颅直流电刺激初级运动皮层和左侧背外侧前额叶对冻结步态及相关结果的影响。
20 名帕金森病伴冻结步态的患者在 3 次单独就诊时接受了 20 分钟的经颅直流电刺激。经颅直流电刺激同时靶向初级运动皮层和左侧背外侧前额叶、仅靶向初级运动皮层或假刺激（顺序随机和双盲评估）。参与者在每次经颅直流电刺激前后完成了冻结步态诱发试验、计时起立行走试验和斯特鲁普测试。
在初级运动皮层和左侧背外侧前额叶同时刺激后，冻结步态诱发试验（P=0.010）、计时起立行走试验（P=0.006）和斯特鲁普测试（P=0.016）的表现得到改善，但仅刺激初级运动皮层或假刺激后没有改善。
旨在同时靶向运动和认知区域的经颅直流电刺激显然会在大脑中引起即时的后续效应，从而减少冻结步态，并改善执行功能和活动能力。© 2018 国际帕金森病和运动障碍学会。
