听觉间隙检测期间的电生理反应：自闭症谱系障碍中感觉和交流改变的生物标志物？
Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
作者信息
Foss-Feig Jennifer H, Stavropoulos Katherine K M, McPartland James C, Wallace Mark T, Stone Wendy L, Key Alexandra P
机构信息
a Department of Psychiatry , Icahn School of Medicine at Mount Sinai Hospital , One Gustave Levy Place, New York , New York.
b Seaver Autism Center , Icahn School of Medicine at Mount Sinai Hospital , One Gustave Levy Place, New York , New York.
出版信息
Dev Neuropsychol. 2018;43(2):109-122. doi: 10.1080/87565641.2017.1365869.
Abstract
Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features. These results suggest that neural response during auditory gap detection is a promising ASD biomarker that could be useful for stratifying subgroups and evaluating treatment response.
摘要
感觉症状，包括听觉处理缺陷，在自闭症谱系障碍（ASD）中很常见。对听觉输入的时间方面的处理研究较少；然而，这一领域的缺陷可能导致与语言相关的障碍。在患有ASD的儿童和匹配良好的对照组中，本研究检测了对听觉刺激中无声间隙的电生理反应。结果显示，ASD患者P2事件相关电位（ERP）成分的振幅减弱。P2振幅降低还与感觉、语言和诊断特征相关。这些结果表明，听觉间隙检测期间的神经反应是一种很有前景的ASD生物标志物，可用于对亚组进行分层和评估治疗反应。
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