The Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Department of Psychology, Fordham University, Bronx, NY, 10458, USA.
J Neurodev Disord. 2023 Apr 1;15(1):11. doi: 10.1186/s11689-023-09480-2.
Atypical auditory cortical processing is consistently found in scalp electrophysiological and magnetoencephalographic studies of Autism Spectrum Disorder (ASD), and may provide a marker of neuropathological brain development. However, the relationship between atypical cortical processing of auditory information and adaptive behavior in ASD is not yet well understood.
We sought to test the hypothesis that early (100-175 ms) auditory processing in ASD is related to everyday adaptive behavior through the examination of auditory event-related potentials (AEPs) in response to simple tones and Vineland Adaptive Behavior Scales in a large cohort of children with ASD (N = 84), aged 6-17, and in age- and IQ- matched neurotypically (NT) developing controls (N = 132).
Statistical analyses revealed significant group differences in early AEPs over temporal scalp regions (150-175 ms), and the expected rightward lateralization of the AEP (100-125 ms and 150-175 ms) to tonal stimuli in both groups. Lateralization of the AEP (150-175 ms) was significantly associated with adaptive functioning in the socialization domain.
These results lend support to the hypothesis that atypical processing of sensory information is related to everyday adaptive behavior in autism.
在自闭症谱系障碍（ASD）的头皮电生理和脑磁图研究中，一直发现非典型的听觉皮质处理，这可能是神经病理学大脑发育的标志。然而，听觉信息的非典型皮质处理与 ASD 中的适应行为之间的关系尚不清楚。
我们试图通过检查 ASD 儿童（N=84，年龄 6-17 岁）和年龄和智商匹配的神经典型（NT）发育对照组（N=132）对简单音调的听觉事件相关电位（AEPs）和文兰适应行为量表，来检验 ASD 中早期（100-175 毫秒）听觉处理与日常适应行为有关的假设。
统计分析显示，两组在颞区头皮的早期 AEP 上存在显著的组间差异（150-175 毫秒），以及 AEP（100-125 毫秒和 150-175 毫秒）对音调刺激的预期右侧偏侧化。AEP 的偏侧化（150-175 毫秒）与社交领域的适应功能显著相关。
这些结果支持这样一种假设，即感觉信息的非典型处理与自闭症中的日常适应行为有关。
