Haybar Habib, Jalali Mohammad Taha, Zayeri Zeinab Deris
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Hyperlipidemia Research Center, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cardiovasc Hematol Disord Drug Targets. 2018;18(2):147-152. doi: 10.2174/1871529X18666180212114305.
Long-term diabetes causes other disease development such as cardiovascular diseases (CVD).
Genetics can help us to predict cardiovascular diseases in diabetic patients.
We searched PubMed and Google scholar for the terms: Cardiovascular disease, Diabetes, Polymorphism, Genetics from 2000 to 2017, and then included the relevant studies in our study.
Essential role of inheritance in multifactorial disease is obviously clear, however, varies by disease and by other factors such as age of disease onset and subtype of disease. CVD is a multifactorial disease which can develop in diabetes patients as a result of increase in oxidative stress. It may also increase expression of pro-inflammatory factors and induce apoptosis in cardiomyocytes.
Predictive polymorphisms are risk estimators for CVD incidence in diabetes patients. SNPs such as 894G>T in NOS3 gene, V16 in MnSOD gene, Rs3918188 in NOS3 gene and Rs11614913 in MiR-196a2 increase the risk of CVD in diabetic patients are precious polymorphisms for CVD prediction in diabetic population. CDKN2B, MTHFR and ACE genes have polymorphisms which increase the risk of diabetes and other polymorphisms on these genes increase the risk of CVD, we suggest these genes are valuable to study and find out if there are any polymorphisms that predict CVD susceptibility in diabetic patients.
长期糖尿病会引发其他疾病，如心血管疾病（CVD）。
遗传学有助于我们预测糖尿病患者的心血管疾病。
我们在PubMed和谷歌学术上搜索了2000年至2017年期间的以下术语：心血管疾病、糖尿病、多态性、遗传学，然后将相关研究纳入我们的研究。
遗传因素在多因素疾病中的重要作用显而易见，但因疾病以及其他因素（如疾病发病年龄和疾病亚型）而异。心血管疾病是一种多因素疾病，糖尿病患者中由于氧化应激增加可引发该疾病。它还可能增加促炎因子的表达并诱导心肌细胞凋亡。
预测性多态性是糖尿病患者心血管疾病发病率的风险评估指标。诸如NOS3基因中的894G>T、MnSOD基因中的V16、NOS3基因中的Rs3918188以及MiR-196a2中的Rs11614913等单核苷酸多态性（SNP）增加了糖尿病患者患心血管疾病的风险，是预测糖尿病患者心血管疾病的重要多态性指标。CDKN2B、MTHFR和ACE基因存在增加糖尿病风险的多态性，而这些基因上的其他多态性则增加心血管疾病风险，我们建议对这些基因进行研究，以确定是否存在预测糖尿病患者心血管疾病易感性的多态性。
