San Buenaventura University, Diagonal 32 # 30-966, Cartagena, Colombia.
Pontificia Javeriana University, Street 18 # 118-250, Cali, Colombia.
Food Funct. 2018 Mar 1;9(3):1570-1577. doi: 10.1039/c7fo01956d. Epub 2018 Feb 13.
The postprandial stage is related to cardiovascular risk and it depends on the type of meal consumed. We study the effects of Sacha inchi oil on the postprandial glycemic state caused by meals rich in saturated fat.
A double blind randomized trial in which 42 adult men ingested two breakfasts rich in saturated fat, one of them containing additionally 15 mL of Sacha inchi oil. Blood samples were obtained before or after 1 and 4 hours post-ingestion to quantify glucose, insulin and lipid profile in serum. The insulinogenic and sensitivity indices were calculated and the expression of sirtuin-1 in circulating mononuclear cells by qPCR was determined.
Oil addition attenuated the increase of glucose in 16 (38.1%) participants. This group showed a higher concentration of fasting triacylglycerides and sirtuin-1 expression at 4 hours post-Sacha inchi oil correlated with glucose at the same time (r = -0.724; p = 0.012), and with postprandial insulin sensitivity (r = 0.636; p = 0.035).
The addition of Sacha inchi oil to a highly fatty meal improves insulin sensitivity in people with higher basal triglyceridemia and higher glycemic responses after a fat load. Under these conditions, sirtuin-1 expression correlates with postprandial insulin sensitivity.
餐后阶段与心血管风险有关，其取决于所摄入的餐食类型。我们研究了 Sacha inchi 油对富含饱和脂肪的餐食引起的餐后血糖状态的影响。
这是一项双盲随机试验，其中 42 名成年男性摄入了两份富含饱和脂肪的早餐，其中一份额外添加了 15 毫升 Sacha inchi 油。在摄入后 1 小时和 4 小时采集血样，以定量测定血清中的葡萄糖、胰岛素和脂质谱。计算胰岛素生成和敏感性指数，并通过 qPCR 测定循环单核细胞中 Sirtuin-1 的表达。
添加油可使 16 名（38.1%）参与者的血糖升高得到缓解。该组在 Sacha inchi 油摄入后 4 小时的空腹三酰甘油浓度和 Sirtuin-1 表达更高，与同一时间的血糖呈负相关（r = -0.724；p = 0.012），并且与餐后胰岛素敏感性相关（r = 0.636；p = 0.035）。
在富含脂肪的餐食中添加 Sacha inchi 油可改善基础三酰甘油水平较高且脂肪负荷后血糖反应较高的人群的胰岛素敏感性。在这些条件下，Sirtuin-1 表达与餐后胰岛素敏感性相关。
