a Department of Vitreo-retina Services , Aravind Eye Hospital , Madurai , Tamil Nadu , India.
b Department of Ocular Microbiology , Aravind Eye Hospital , Madurai , Tamil Nadu , India.
Ocul Immunol Inflamm. 2018;26(4):559-568. doi: 10.1080/09273948.2018.1430238. Epub 2018 Feb 13.
To report the incidence and characteristics of endophthalmitis after intravitreal injections (IVI) of antivascular endothelial growth factor agents and triamcinolone acetonide.
Patients' medical records were retrospectively reviewed from January 2009 to June 2016, and the incidence, risk factors, clinical and microbiological characteristics of post-IVI endophthalmitis were evaluated.
The total number of intravitreal injections given, which included ranibizumab, bevacizumab, and triamcinolone acetonide, was 20,566, of which 27 cases developed endophthalmitis, giving an overall incidence of 0.131%. Significant reduction (p < 0.003) in incidence of endophthalmitis was observed in patients who received prefilled compounded bevacizumab injections (0.050%) compared to multiple bevacizumab injections from a single vial (0.235%). In the triamcinolone acetonide group, the incidence was 0.26%. Staphylococcus species were isolated from 18 cases (67%), and all strains were sensitive to vancomycin.
Adherence to strict aseptic protocols and use of prefilled compounded bevacizumab injections reduces the rate of post-IVI endophthalmitis.
报告玻璃体内注射抗血管内皮生长因子药物和曲安奈德后眼内炎的发生率和特征。
回顾性分析 2009 年 1 月至 2016 年 6 月的患者病历，评估玻璃体内注射后眼内炎的发生率、危险因素、临床和微生物学特征。
共进行了 20566 次玻璃体内注射，包括雷珠单抗、贝伐单抗和曲安奈德，其中 27 例发生眼内炎，总发生率为 0.131%。与单次使用一瓶贝伐单抗相比，接受预装复合贝伐单抗注射的患者眼内炎发生率显著降低（p<0.003，0.050% vs. 0.235%）。在曲安奈德组，发生率为 0.26%。18 例（67%）分离出葡萄球菌属，所有菌株对万古霉素均敏感。
严格遵守无菌操作规程和使用预装复合贝伐单抗注射可降低玻璃体内注射后眼内炎的发生率。
