Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, Australia.
Faculty of Health Sciences, School of Medicine, University of Adelaide, Adelaide, Australia.
Gut. 2018 May;67(5):973-985. doi: 10.1136/gutjnl-2017-315655. Epub 2018 Feb 3.
Evolution of treatment targets in IBD has increased the need for objective monitoring of disease activity to guide therapeutic strategy. Although mucosal healing is the current target of therapy in IBD, endoscopy is invasive, expensive and unappealing to patients. GI ultrasound (GIUS) represents a non-invasive modality to assess disease activity in IBD. It is accurate, cost-effective and reproducible. GIUS can be performed at the point of care without specific patient preparation so as to facilitate clinical decision-making. As compared with ileocolonoscopy and other imaging modalities (CT and MRI), GIUS is accurate in diagnosing IBD, detecting complications of disease including fistulae, strictures and abscesses, monitoring disease activity and detecting postoperative disease recurrence. International groups increasingly recognise GIUS as a valuable tool with paradigm-changing application in the management of IBD; however, uptake outside parts of continental Europe has been slow and GIUS is underused in many countries. The aim of this review is to present a pragmatic guide to the positioning of GIUS in IBD clinical practice, providing evidence for use, algorithms for integration into practice, training pathways and a strategic implementation framework.
炎症性肠病(IBD)治疗靶点的演变增加了客观监测疾病活动以指导治疗策略的需求。尽管黏膜愈合是 IBD 目前的治疗靶点,但内镜检查具有侵袭性、昂贵且不受患者欢迎。胃肠超声(GIUS)代表了一种评估 IBD 疾病活动的非侵入性方法。它准确、具有成本效益且可重复。GIUS 可以在床边进行,无需特定的患者准备,从而有利于临床决策。与回结肠镜检查和其他成像方式(CT 和 MRI)相比,GIUS 准确诊断 IBD,检测疾病的并发症,包括瘘管、狭窄和脓肿,监测疾病活动并检测术后疾病复发。国际组织越来越认识到 GIUS 是一种有价值的工具,在 IBD 的管理中具有改变范式的应用;然而,在欧洲大陆以外的地区,GIUS 的使用率较低,在许多国家的应用不足。本综述旨在为 GIUS 在 IBD 临床实践中的定位提供实用指南,为其使用提供证据,提出将其纳入实践的算法、培训途径和战略实施框架。