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人类中抗原受体特异性抑制性T细胞克隆的产生。

Generation of antigen receptor-specific suppressor T cell clones in man.

作者信息

Mohagheghpour N, Damle N K, Takada S, Engleman E G

出版信息

J Exp Med. 1986 Sep 1;164(3):950-5. doi: 10.1084/jem.164.3.950.

DOI:10.1084/jem.164.3.950
PMID:2943852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188398/
Abstract

We have shown previously that CD8+ T cells proliferate upon exposure to autologous, antigen primed CD4+ T cells, and suppress the response of fresh T cells to the priming antigen but not irrelevant antigens. The stimulus and target of suppression in this system appears to be the antigen receptor on the surface of CD4+ cells, rather than the nominal antigen. In the current study, alloantigen primed CD4+ inducer cells and IL-2-containing medium were used to generate clones of suppressor cells from several individuals. The clones inhibited the response of fresh autologous T cells only to the original allogeneic stimulator cell and to stimulator cells that shared HLA-DR antigens with the priming cell. The clones were also genetically restricted, since they inhibited the response of HLA-A,B-compatible but not HLA-A,B-incompatible individuals. The availability of a method for reproducibly generating antigen receptor-specific suppressor T cell clones in vitro should make it possible to clarify the mechanism, whereby such cells are activated and exert their suppressive effect.

摘要

我们之前已经表明，CD8+ T细胞在接触自体、经抗原致敏的CD4+ T细胞后会增殖，并抑制新鲜T细胞对致敏抗原的反应，但不抑制对无关抗原的反应。该系统中抑制的刺激因素和靶点似乎是CD4+细胞表面的抗原受体，而非名义上的抗原。在当前研究中，使用经同种异体抗原致敏的CD4+诱导细胞和含白细胞介素-2的培养基从多个个体中生成抑制细胞克隆。这些克隆仅抑制新鲜自体T细胞对原始同种异体刺激细胞以及与致敏细胞共享HLA-DR抗原的刺激细胞的反应。这些克隆在遗传上也具有限制性，因为它们抑制HLA-A、B相容个体的反应，但不抑制HLA-A、B不相容个体的反应。体外可重复生成抗原受体特异性抑制性T细胞克隆的方法的可用性，应该能够阐明此类细胞被激活并发挥其抑制作用的机制。

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本文引用的文献

1
A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression.抗原特异性免疫抑制中T淋巴细胞相互作用的单一主要途径。
Scand J Immunol. 1981;13(1):1-10. doi: 10.1111/j.1365-3083.1981.tb00104.x.
2
Long-term suppressor cell lines. I. Demonstration of suppressive function.
Eur J Immunol. 1984 Dec;14(12):1073-9. doi: 10.1002/eji.1830141202.
3
Immunoregulatory T cell circuits in man. Alloantigen-primed inducer T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus.人类的免疫调节性T细胞回路。同种异体抗原致敏的诱导性T细胞在没有初始抗原刺激的情况下激活同种异体抗原特异性抑制性T细胞。
J Exp Med. 1983 Jul 1;158(1):159-73. doi: 10.1084/jem.158.1.159.
4
A human suppressor T cell clone which recognizes an autologous helper T cell clone.一个识别自身辅助性T细胞克隆的人类抑制性T细胞克隆。
Nature. 1982 Dec 2;300(5891):456-8. doi: 10.1038/300456a0.
5
Activation of antigen-specific suppressor T lymphocytes in man involves dual recognition of self class I MHC molecules and Leu-4/T3-associated structures on the surface of inducer T lymphocytes.人类中抗原特异性抑制性T淋巴细胞的激活涉及对自身I类MHC分子以及诱导性T淋巴细胞表面Leu-4/T3相关结构的双重识别。
J Immunol. 1984 Sep;133(3):1235-40.
6
A human alloreactive inducer T cell clone that selectively activates antigen-specific suppressor T cells.
J Immunol. 1984 Jul;133(1):133-6.
7
Soluble antigen-primed inducer T cells activate antigen-specific suppressor T cells in the absence of antigen-pulsed accessory cells: phenotypic definition of suppressor-inducer and suppressor-effector cells.可溶性抗原致敏的诱导性T细胞在不存在抗原脉冲辅助细胞的情况下激活抗原特异性抑制性T细胞：抑制诱导细胞和抑制效应细胞的表型定义
J Immunol. 1984 Feb;132(2):644-50.
8
T cell regulation of B cell activation. I-A-restricted T suppressor cells inhibit the major histocompatibility complex-restricted interactions of T helper cells with B cells and accessory cells.T细胞对B细胞激活的调节作用。I-A限制性T抑制细胞抑制T辅助细胞与B细胞及辅助细胞之间主要组织相容性复合体限制性相互作用。
J Exp Med. 1983 Jun 1;157(6):1867-84. doi: 10.1084/jem.157.6.1867.
9
Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity.抗原特异性T淋巴细胞克隆。I. 表达抗原特异性抑制活性的T淋巴细胞克隆的特性
J Exp Med. 1981 May 1;153(5):1246-59. doi: 10.1084/jem.153.5.1246.
10
Antigen-specific suppressor T lymphocytes in man make use of the same set of surface molecules as do cytolytic T lymphocytes: roles of Leu-2/T8, Leu-4/T3, Leu-5/T11, LFA-1 molecules.人类中的抗原特异性抑制性T淋巴细胞利用与细胞溶解性T淋巴细胞相同的一组表面分子：Leu-2/T8、Leu-4/T3、Leu-5/T11、LFA-1分子的作用。
J Immunol. 1985 Sep;135(3):1724-30.

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