• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Generation of antigen receptor-specific suppressor T cell clones in man.人类中抗原受体特异性抑制性T细胞克隆的产生。
J Exp Med. 1986 Sep 1;164(3):950-5. doi: 10.1084/jem.164.3.950.
2
Differences in surface phenotype and mechanism of action between alloantigen-specific CD8+ cytotoxic and suppressor T cell clones.同种抗原特异性CD8 + 细胞毒性和抑制性T细胞克隆之间的表面表型和作用机制差异。
J Immunol. 1990 Jan 1;144(1):32-40.
3
Alloantigen-specific T suppressor-inducer and T suppressor-effector cells can be activated despite blocking the IL-2 receptor.尽管阻断了白细胞介素-2受体，但同种异体抗原特异性T抑制诱导细胞和T抑制效应细胞仍可被激活。
J Immunol. 1990 Jul 15;145(2):485-8.
4
Phenotypic and functional characterization of human suppressor T-cell clones: II. Activation by Mycobacterium leprae presented by HLA-DR molecules to alpha beta T-cell receptors.人类抑制性T细胞克隆的表型和功能特征：II. 由HLA-DR分子呈递给αβT细胞受体的麻风分枝杆菌激活作用。
Hum Immunol. 1990 May;28(1):11-26. doi: 10.1016/0198-8859(90)90098-a.
5
"Tolerization" of human T-helper cell clones by chronic exposure to alloantigen: culture conditions dictate autocrine proliferative status but not acquisition of cytotoxic potential and suppressor-induction capacity.通过长期暴露于同种异体抗原使人类辅助性T细胞克隆“耐受化”：培养条件决定自分泌增殖状态，但不影响细胞毒性潜能的获得和抑制诱导能力。
J Mol Cell Immunol. 1988;4(1):21-34.
6
Alloantigen-specific cytotoxic clones bearing the alpha,beta T cell antigen receptor but not CD4 or CD8 molecules.携带α、β T细胞抗原受体但不携带CD4或CD8分子的同种异体抗原特异性细胞毒性克隆。
J Immunol. 1990 Jul 15;145(2):470-6.
7
Antigen-specific suppressor T lymphocytes in man.
Clin Immunol Immunopathol. 1989 Nov;53(2 Pt 2):S17-24. doi: 10.1016/0090-1229(89)90066-4.
8
Immunological suppression by human CD8+ T cells is receptor dependent and HLA-DQ restricted.人类CD8+ T细胞介导的免疫抑制是受体依赖性的且受HLA-DQ限制。
Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2598-602. doi: 10.1073/pnas.88.6.2598.
9
Activation of antigen-specific suppressor T lymphocytes in man involves dual recognition of self class I MHC molecules and Leu-4/T3-associated structures on the surface of inducer T lymphocytes.人类中抗原特异性抑制性T淋巴细胞的激活涉及对自身I类MHC分子以及诱导性T淋巴细胞表面Leu-4/T3相关结构的双重识别。
J Immunol. 1984 Sep;133(3):1235-40.
10
AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens.可溶性 HLA - DR 抗原体外激活的人 T 淋巴细胞的 AMLR 和 MLR 刺激活性。
Clin Exp Immunol. 1986 Jan;63(1):163-70.

引用本文的文献

1
Autoreactive CD4- CD8- alpha beta T cells to vaccinate adjuvant arthritis.针对佐剂性关节炎的自身反应性CD4 - CD8 - αβ T细胞。
Immunology. 1998 Aug;94(4):536-42. doi: 10.1046/j.1365-2567.1998.00543.x.
2
Type-1 and type-2 CD8+ T-cell subsets isolated from chronic adult periodontitis tissue differ in surface phenotype and biological functions.从慢性成人牙周炎组织中分离出的1型和2型CD8 + T细胞亚群在表面表型和生物学功能上存在差异。
Immunology. 1996 Jan;87(1):113-8.
3
T cell blast stimulation of MLR: role of interleukin 1 and interleukin 2.混合淋巴细胞反应中T细胞母细胞刺激：白细胞介素1和白细胞介素2的作用
Clin Exp Immunol. 1988 Jan;71(1):171-6.
4
MHC-restricted minimal regulatory circuit initiated by a class II-autoreactive T cell clone.由II类自身反应性T细胞克隆启动的MHC限制的最小调节回路。
J Exp Med. 1987 May 1;165(5):1284-95. doi: 10.1084/jem.165.5.1284.
5
Inhibition of antiskin allograft immunity induced by infusions with photoinactivated effector T lymphocytes (PET cells).通过输注光灭活效应T淋巴细胞（PET细胞）诱导的抗皮肤同种异体移植免疫的抑制作用。
Yale J Biol Med. 1989 Nov-Dec;62(6):595-609.
6
Immune suppression genes.免疫抑制基因。
Clin Exp Immunol. 1989 Feb;75(2):167-77.
7
Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.环孢素治疗后心脏同种异体移植长期存活大鼠的特异性无反应性。III. CD4 + 抑制细胞的进一步特征及其作用机制
J Exp Med. 1990 Jan 1;171(1):141-57. doi: 10.1084/jem.171.1.141.

本文引用的文献

1
A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression.抗原特异性免疫抑制中T淋巴细胞相互作用的单一主要途径。
Scand J Immunol. 1981;13(1):1-10. doi: 10.1111/j.1365-3083.1981.tb00104.x.
2
Long-term suppressor cell lines. I. Demonstration of suppressive function.
Eur J Immunol. 1984 Dec;14(12):1073-9. doi: 10.1002/eji.1830141202.
3
Immunoregulatory T cell circuits in man. Alloantigen-primed inducer T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus.人类的免疫调节性T细胞回路。同种异体抗原致敏的诱导性T细胞在没有初始抗原刺激的情况下激活同种异体抗原特异性抑制性T细胞。
J Exp Med. 1983 Jul 1;158(1):159-73. doi: 10.1084/jem.158.1.159.
4
A human suppressor T cell clone which recognizes an autologous helper T cell clone.一个识别自身辅助性T细胞克隆的人类抑制性T细胞克隆。
Nature. 1982 Dec 2;300(5891):456-8. doi: 10.1038/300456a0.
5
Activation of antigen-specific suppressor T lymphocytes in man involves dual recognition of self class I MHC molecules and Leu-4/T3-associated structures on the surface of inducer T lymphocytes.人类中抗原特异性抑制性T淋巴细胞的激活涉及对自身I类MHC分子以及诱导性T淋巴细胞表面Leu-4/T3相关结构的双重识别。
J Immunol. 1984 Sep;133(3):1235-40.
6
A human alloreactive inducer T cell clone that selectively activates antigen-specific suppressor T cells.
J Immunol. 1984 Jul;133(1):133-6.
7
Soluble antigen-primed inducer T cells activate antigen-specific suppressor T cells in the absence of antigen-pulsed accessory cells: phenotypic definition of suppressor-inducer and suppressor-effector cells.可溶性抗原致敏的诱导性T细胞在不存在抗原脉冲辅助细胞的情况下激活抗原特异性抑制性T细胞：抑制诱导细胞和抑制效应细胞的表型定义
J Immunol. 1984 Feb;132(2):644-50.
8
T cell regulation of B cell activation. I-A-restricted T suppressor cells inhibit the major histocompatibility complex-restricted interactions of T helper cells with B cells and accessory cells.T细胞对B细胞激活的调节作用。I-A限制性T抑制细胞抑制T辅助细胞与B细胞及辅助细胞之间主要组织相容性复合体限制性相互作用。
J Exp Med. 1983 Jun 1;157(6):1867-84. doi: 10.1084/jem.157.6.1867.
9
Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity.抗原特异性T淋巴细胞克隆。I. 表达抗原特异性抑制活性的T淋巴细胞克隆的特性
J Exp Med. 1981 May 1;153(5):1246-59. doi: 10.1084/jem.153.5.1246.
10
Antigen-specific suppressor T lymphocytes in man make use of the same set of surface molecules as do cytolytic T lymphocytes: roles of Leu-2/T8, Leu-4/T3, Leu-5/T11, LFA-1 molecules.人类中的抗原特异性抑制性T淋巴细胞利用与细胞溶解性T淋巴细胞相同的一组表面分子：Leu-2/T8、Leu-4/T3、Leu-5/T11、LFA-1分子的作用。
J Immunol. 1985 Sep;135(3):1724-30.

人类中抗原受体特异性抑制性T细胞克隆的产生。

Generation of antigen receptor-specific suppressor T cell clones in man.

作者信息

Mohagheghpour N, Damle N K, Takada S, Engleman E G

出版信息

J Exp Med. 1986 Sep 1;164(3):950-5. doi: 10.1084/jem.164.3.950.

DOI:10.1084/jem.164.3.950
PMID:2943852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188398/
Abstract

We have shown previously that CD8+ T cells proliferate upon exposure to autologous, antigen primed CD4+ T cells, and suppress the response of fresh T cells to the priming antigen but not irrelevant antigens. The stimulus and target of suppression in this system appears to be the antigen receptor on the surface of CD4+ cells, rather than the nominal antigen. In the current study, alloantigen primed CD4+ inducer cells and IL-2-containing medium were used to generate clones of suppressor cells from several individuals. The clones inhibited the response of fresh autologous T cells only to the original allogeneic stimulator cell and to stimulator cells that shared HLA-DR antigens with the priming cell. The clones were also genetically restricted, since they inhibited the response of HLA-A,B-compatible but not HLA-A,B-incompatible individuals. The availability of a method for reproducibly generating antigen receptor-specific suppressor T cell clones in vitro should make it possible to clarify the mechanism, whereby such cells are activated and exert their suppressive effect.

摘要

我们之前已经表明，CD8+ T细胞在接触自体、经抗原致敏的CD4+ T细胞后会增殖，并抑制新鲜T细胞对致敏抗原的反应，但不抑制对无关抗原的反应。该系统中抑制的刺激因素和靶点似乎是CD4+细胞表面的抗原受体，而非名义上的抗原。在当前研究中，使用经同种异体抗原致敏的CD4+诱导细胞和含白细胞介素-2的培养基从多个个体中生成抑制细胞克隆。这些克隆仅抑制新鲜自体T细胞对原始同种异体刺激细胞以及与致敏细胞共享HLA-DR抗原的刺激细胞的反应。这些克隆在遗传上也具有限制性，因为它们抑制HLA-A、B相容个体的反应，但不抑制HLA-A、B不相容个体的反应。体外可重复生成抗原受体特异性抑制性T细胞克隆的方法的可用性，应该能够阐明此类细胞被激活并发挥其抑制作用的机制。