Zhang Shiying, Wu Hao, Zhou Heng, Liang Liang
Department of Pathology, Renmin Hospital of Wuhan University, Hubei Zhang Road (formerly Ziyang Road), Wuchang District No. 99 Jiefang Road 238, Wuhan, Hubei province, China.
Department of Pathology, Renmin Hospital of Wuhan University, Hubei Zhang Road (formerly Ziyang Road), Wuchang District No. 99 Jiefang Road 238, Wuhan, Hubei province, China.
Neurosci Lett. 2018 Apr 3;671:66-69. doi: 10.1016/j.neulet.2018.02.013. Epub 2018 Feb 10.
Previous studies have investigated the association between ADH1C 1/2 polymorphism and alcohol dependence (AD), but have yielded controversial results in Turkey. Therefore, in an effort to illustrate whether ADH1C 1/2 polymorphism is associated with AD risk in Turkish population, we used meta analysis to synthetically evaluate the effect of ADH1C 1/2 polymorphism on AD. Publications were identified by searching in PubMed and EMBASE databases. Four eligible studies involving 400 controls and 421 cases were included in this study. Overall, there is a significant association between ADH1C 1/2 polymorphism and AD risk in the allelic model (OR = 1.66, 95% CI = 1.05-2.62, P = 0.03) and recessive model (OR = 1.72, 95% CI = 1.14-2.58, P = 0.01), while no significance was discovered in the dominant genetic model, homozygote model and heterozygotemodel. No publication bias was indicated from Begg's and Egger's test. Our meta-analysis results suggested that a potential relationship between ADH1C 1/2 polymorphism and AD risk in Turkish population. Further studies are confirmed to resolve this question about the etiological mechanisms of the correlation.
先前的研究调查了乙醇脱氢酶1C（ADH1C）1/2多态性与酒精依赖（AD）之间的关联，但在土耳其得出了有争议的结果。因此，为了阐明ADH1C 1/2多态性是否与土耳其人群的AD风险相关，我们采用荟萃分析来综合评估ADH1C 1/2多态性对AD的影响。通过检索PubMed和EMBASE数据库来识别相关出版物。本研究纳入了四项符合条件的研究，涉及400名对照和421例病例。总体而言，在等位基因模型（OR = 1.66，95% CI = 1.05 - 2.62，P = 0.03）和隐性模型（OR = 1.72，95% CI = 1.14 - 2.58，P = 0.01）中，ADH1C 1/2多态性与AD风险之间存在显著关联，而在显性遗传模型、纯合子模型和杂合子模型中未发现显著关联。Begg检验和Egger检验均未显示出发表偏倚。我们的荟萃分析结果表明，土耳其人群中ADH1C 1/2多态性与AD风险之间存在潜在关系。需要进一步的研究来解决关于这种相关性病因机制的这一问题。
